Results 151 to 160 of about 7,747 (217)
Advanced Science, EarlyView.This study develops lipid nanoparticle‐encapsulated mRNA‐encoding antibodies (mRNab‐LNPs) targeting CD19, demonstrating robust anti‐CD19 antibody production in vivo. Intramuscular injection of mRNab‐LNPs reduces CD19+ B and plasma cells in lupus and rheumatoid arthritis mice, significantly alleviating histopathological changes and tissue injuries of ...
Chipeng Guo +10 more
wiley +1 more source
Clinical overview on RASopathies
American Journal of Medical Genetics Part C: Seminars in Medical Genetics, Volume 190, Issue 4, Page 414-424, December 2022., 2022 Abstract RASopathies comprise a group of clinically overlapping developmental disorders caused by genetic variations affecting components or modulators of the RAS‐MAPK signaling cascade, which lead to dysregulation of signal flow through this pathway.
Martin Zenker
wiley +1 more source
Advanced Science, EarlyView.This work maps 3′‐UTR APA across mouse fetal development and tissues, identifying conserved sequence determinants that influence pAS choice. In fetal brain tissues, complex APA dynamics during development are potentially regulated by RBPs like Rbm38, which restrict distal pAS usage.
Qin Wang, Xin Chen, Xiao‐Ou Zhang
wiley +1 more source
Implantable Biophotonic Device for Wirelessly Cancer Real‐Time Monitoring and Modulable Treatment
Advanced Science, EarlyView.A wirelessly implantable biophotonic device is capable of distinguishing tumors and evaluating their progression by monitoring sO2 levels indicative of the tumor hypoxic microenvironment. Additionally, this device is not only employed for in situ PDT but also for concurrent monitoring of chemotherapy and PDT progress, thereby enabling the evaluation ...
Renhao Nie +8 more
wiley +1 more source
AGING MEDICINE, EarlyView.This article mainly introduces the pathologic process of sarcopenia and the recent progress in diagnosis and treatment, especially the nondrug treatment. ABSTRACT Sarcopenia refers to the progressive decline and wasting of skeletal muscle function, typically linked to aging or as a secondary effect of various conditions, including systemic inflammation,
Qi‐Fei Kuang +2 more
wiley +1 more source
Annals of Gastroenterological Surgery, EarlyView.This paper demonstrates that revisional/redo ileal pouch anal anastomosis (IPAA) surgery with concurrent biologic therapy provides a viable, stoma‐free alternative for patients with Crohn's disease‐like complications, showing a high functioning pouch rate and expanding options for managing pouch failure.
Mehmet Gulmez +8 more
wiley +1 more source
Aggregate, EarlyView.An anti‐inflammatory and antioxidant metal‐organic framework (MOF) nanoplatform was prepared via one‐pot self‐assembly. In vitro and in vivo studies demonstrated that the prepared MVPC nanoparticles can effectively scavenge overproduced reactive oxygen species at diseased sites, enhance IL‐10 secretion, and suppress VEGFA expression, offering a novel ...
Shundong Cai +12 more
wiley +1 more source
Advanced Intelligent Discovery, EarlyView.This paper describes the basis for AInsectID Version 1, a GUI‐operable open‐source insect species identification, color processing, and image analysis software. This paper discusses our methods of algorithmic development, coupled to rigorous machine training used to enable high levels of validation accuracy.
Haleema Sadia, Parvez Alam
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