Results 181 to 190 of about 7,747 (217)

Animal models of cisplatin‐induced neuropathic pain

Animal Models and Experimental Medicine, EarlyView.
This article illustrates the modeling process of a cisplatin‐induced neuropathic pain model in rats or mice. Multiple modeling tests are required for rats or mice before, during, and after modeling. The appropriate injection method, dose, and modeling method are selected, and multiple assays are chosen for evaluation and comparison.
Ningxin Li, Mingzhu Li, Shengbo Jin, Jun Yu, Hongzhe Wei, Wenping Wang, Siyao Ma, Yuxin Jiang, Qian Liu, Huini Yao   +9 more
wiley   +1 more source

A Mosaic Hotspot PLCD1 Variant, Detectable in Blood‐Derived DNA, Associated With Nevus Trichilemmocysticus

American Journal of Medical Genetics Part A, EarlyView.
Leanne de Kock, Macarena Nougues, Madeline Couse, Wendy Mears, Alison J. Eaton, Kristin D. Kernohan, Care4Rare Canada Consortium, Margarita Larralde, Kym M. Boycott   +8 more
wiley   +1 more source

Description of unilateral kidney embolism and contralateral nephrectomy as a less invasive remnant kidney model in cats; a proof‐of‐concept study

Animal Models and Experimental Medicine, EarlyView.
Unilateral, minimally invasive, renal arterial embolization and delayed contralateral nephrectomy was described in cats as a novel remnant kidney model of chronic kidney disease using two doses of embolic particles. Renal function declined and characteristic histopathological markers of kidney disease were present 6 months after the embolism procedure.
Chad W. Schmiedt, Bianca N. Lourenço, Lauren E. Markovic, Meghan Lancaster, Sanjeev Gumber, Juliane Wannemacher, Peter Florian, Amanda E. Coleman   +7 more
wiley   +1 more source

Automated Detection of Isolated REM Sleep Behavior Disorder Using Computer Vision

Annals of Neurology, EarlyView.
Objective Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is, in most cases, an early stage of Parkinson's disease or related disorders. Diagnosis requires an overnight video‐polysomnogram (vPSG), however, even for sleep experts, interpreting vPSG data is challenging.
Mohamed Abdelfattah, Li Zhou, Oliver Sum‐Ping, Anahid Hekmat, Joanna Galati, Niraj Gupta, George Adaimi, Salonee Marwaha, Ankit Parekh, Emmanuel Mignot, Alexandre Alahi, Emmanuel During   +11 more
wiley   +1 more source

Spiking Patterns in the Globus Pallidus Highlight Convergent Neural Dynamics across Diverse Genetic Dystonia Syndromes

Annals of Neurology, EarlyView.
Objective Genetic dystonia is a complex movement disorder with diverse clinical manifestations resulting from pathogenic mutations in associated genes. A recent paradigm shift emphasizes the functional convergence among dystonia genes, hinting at a shared pathomechanism. However, the neural dynamics supporting this convergence remain largely unexplored.
Ahmet Kaymak, Fabiana Colucci, Mahboubeh Ahmadipour, Nico Golfrè Andreasi, Sara Rinaldo, Zvi Israel, David Arkadir, Roberta Telese, Vincenzo Levi, Giovanna Zorzi, Jacopo Carpaneto, Miryam Carecchio, Holger Prokisch, Michael Zech, Barbara Garavaglia, Hagai Bergman, Roberto Eleopra, Alberto Mazzoni, Luigi M. Romito   +18 more
wiley   +1 more source

Neuroimaging Predictors of Cognitive Resilience against Alzheimer's Disease Pathology

Annals of Neurology, EarlyView.
Objective Some individuals demonstrate greater cognitive resilience—the ability to maintain cognitive performance despite adverse brain‐related changes—through as yet unknown mechanisms. We examined whether cortical thickness in several brain regions confers resilience against cognitive decline in amyloid‐positive adults by moderating the effects of ...
McKenna E. Williams, Christine Fennema‐Notestine, Tyler R. Bell, Shu‐Ju Lin, Stephen J. Glatt, William S. Kremen, Jeremy A. Elman, for the Alzheimer's Disease Neuroimaging Initiative   +7 more
wiley   +1 more source

Frequency and Early Predictors of Cognitive Deterioration in Amyotrophic Lateral Sclerosis: A Longitudinal Population‐Based Study

Annals of Neurology, EarlyView.
Objective The objective is to evaluate cognitive and behavioral progression and identify early predictors of these changes in a cohort of amyotrophic lateral sclerosis (ALS) patients. Methods A total of 161 ALS patients were tested at diagnosis (T0), and 107 were re‐tested after 1 year (T1) using cognitive/behavioral tests. All patients underwent whole‐
Barbara Iazzolino, Francesca Palumbo, Cristina Moglia, Umberto Manera, Maurizio Grassano, Enrico Matteoni, Sara Cabras, Maura Brunetti, Rosario Vasta, Marco Pagani, Gabriele Mora, Antonio Canosa, Andrea Calvo, Adriano Chiò   +13 more
wiley   +1 more source

Regional Cerebral Atrophy Contributes to Personalized Survival Prediction in Amyotrophic Lateral Sclerosis: A Multicentre, Machine Learning, Deformation‐Based Morphometry Study

Annals of Neurology, EarlyView.
Objective Accurate personalized survival prediction in amyotrophic lateral sclerosis is essential for effective patient care planning. This study investigates whether grey and white matter changes measured by magnetic resonance imaging can improve individual survival predictions.
Isabelle Lajoie, Canadian ALS Neuroimaging Consortium (CALSNIC), Sanjay Kalra, Mahsa Dadar   +3 more
wiley   +1 more source

Cyclic Alternating Pattern Dynamics in Individuals at Risk for Developing Parkinson's Disease

Annals of Neurology, EarlyView.
Objective The objective of this study was to investigate the differences in cyclic alternating patterns (CAP) metrics, a non‐rapid eye movement (NREM) sleep physiological rhythm, among recently diagnosed patients with Parkinson's disease (PD), and individuals at high and low risk for developing PD based on genetic and prodromal risk.
Andrew Dagay, Shlomit Katzav, Danielle Wasserman, Valentina Gnoni, Anat Mirelman, Riva Tauman   +5 more
wiley   +1 more source

Purine Metabolism and Dystonia: Perspectives of a Long‐Promised Relationship

Annals of Neurology, EarlyView.
Purine pool imbalance in purine metabolism disorders, such as Lesch–Nyhan disease, intersects with dystonia pathogenesis. The recent discovery of gain‐of‐function IMPDH2 pathogenic variants in patients with prominent dystonic manifestations provides new insights into the link between dystonia and purinergic system defects.
Ugo Sorrentino, Audrey G. O'Neill, Justin M. Kollman, Hyder A. Jinnah, Michael Zech   +4 more
wiley   +1 more source