Results 111 to 120 of about 94,642 (375)

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

Regenerative Peripheral Nerve Interface Surgery to Treat Chronic Postamputation Pain: A Prospective Study in Major Lower Limb Amputation Patients

Annals of Surgery Open
Objective:. The objective was to assess the postsurgical outcomes of regenerative peripheral nerve interface (RPNI) surgery in a prospective cohort of major lower extremity amputation patients with chronic postamputation pain. Background:.
Jennifer C. Lee, MD, Carrie A. Kubiak, MD, Christine S.W. Best, MD, Jennifer B. Hamill, MPH, Jamie Ki, MS, Hyungjin Myra Kim, ScD, Randy S. Roth, MD, Jeffrey H. Kozlow, MD, Melissa J. Tinney, MD, Michael E. Geisser, MD, Paul S. Cederna, MD, Stephen W.P. Kemp, MD, Theodore A. Kung, MD   +12 more
doaj   +1 more source

Capturing the Perceived Phantom Limb through Virtual Reality [PDF]

, 2015
poster abstractPhantom limb is the sensation amputees may feel where the missing limb (occasionally an organ) is still attached to the body and is still moving as it would if it were there.
Albertson, Steven, Beem, James, Huynh, Denver, Lau, Jonathan, Qian, Enlin   +4 more
core  

Action and non-action oriented body representations. insight from behavioural and grey matter modifications in individuals with lower limb amputation [PDF]

, 2018
Following current model of body representations, we aimed to systematically investigate the association between brain modifications, in terms of grey matter loss, and body representation deficits, in terms of alterations of the body schema (BS) and of ...
Boccia, Maddalena, Brunelli, Stefano, De Giorgi, Roberto, Di Vita, Antonella, Galati, Gaspare, Guariglia, Cecilia, Nemmi, Federico, Palermo, Liana, Traballesi, Marco   +8 more
core   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Passive exercise of the hind limbs after complete thoracic transection of the spinal cord promotes cortical reorganization. [PDF]

, 2013
Physical exercise promotes neural plasticity in the brain of healthy subjects and modulates pathophysiological neural plasticity after sensorimotor loss, but the mechanisms of this action are not fully understood.
Foffani, Guglielmo, Graziano, Alessandro, Knudsen, Eric B, Moxon, Karen A, Shumsky, Jed   +4 more
core   +6 more sources

A case of phantom pain and stump pain that was effectively controlled by ultrasound‐guided ulnar and median peripheral nerve blocks

Clinical Case Reports, 2023
Phantom limb pain and stump pain are often intractable, and their incidences are relatively high. We report a case of a patient with phantom limb and stump pain of the finger, who was successfully treated by peripheral nerve blocks.
Shunya Sekiguchi, Yusuke Ishida, Yosuke Fujita, Mikiko Tomino, Kiyoshige Ohseto   +4 more
doaj   +1 more source

Mirror therapy and self-care autonomy after stroke: an intervention program [PDF]

, 2018
Background: In patients with middle cerebral artery (MCA) stroke, changes in upper limb function lead to dependence on others for self-care. In the process of recovering autonomy/independence, there is evidence on the effectiveness of sensory stimulation
Castro, Pedro, Couto, Glória, Martins, Maria, Reis, Maria   +3 more
core   +1 more source

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

MG53 Coordinates Macrophage Polarization and Neuroimmune Coupling to Promote Corneal Nerve Regeneration via the MPEG1–MVP–STAT6 Axis

Advanced Science, EarlyView.
Corneal nerve regeneration is critical to corneal wound healing processes. The current study reveals a novel role of MG53 in promoting corneal nerve regeneration after alkali induced injury. Mechanistically, MG53 enters macrophages via its receptor, MPEG1, promotes MVP K63 ubiquitination, and triggers STAT6 induced repair‐related genes expression ...
Peng Chen, Zhentao Zhang, Lilian Sakai, Yanping Xu, Luxi Zhang, Han Ye, William Sollenberger, Takahide Ikeda, Zhiyu Yan, Keerthika Sathish, Usman Alizai, Haitao Wen, Timothy M. Pawlik, Heather L. Chandler, Hua Zhu   +14 more
wiley   +1 more source