Results 61 to 70 of about 7,965 (289)
Advanced Science, EarlyView.Spatial transcriptomics reveals a remodeled fibroblast‐immune microenvironment in the temporomandibular joint (TMJ) during arthritis. By combining seqFISH with genetic mouse models, this study uncovers TMJ spatial cell atalas, macrophage‐fibroblast crosstalk, and cytokine signaling pathways driving TMJ inflammation and pain.
Ziying Lin +10 more
wiley +1 more source
Pain Research and Management, 2018 Multimodal analgesia may include pharmacological components such as regional anesthesia, opioid and nonopioid systemic analgesics, nonsteroidal anti-inflammatories, and a variety of adjuvant agents. Multimodal analgesia has been reported for a variety of
Roberta De Jong, Alexander J. Shysh
doaj +1 more source
Appearance of phantom limb pain after spinal anesthesia
Indian Journal of Pain, 2016 Phantom limb pain which is basically neuropathic in nature resulting from functional changes in peripheral and central pain pathways subsequent to amputation, is challenging to treat.
Rajmala Jaiswal +3 more
doaj +1 more source
Advanced Science, EarlyView.Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian +13 more
wiley +1 more source
Modern concepts of treatment of phantom limb pain [PDF]
, 2023 Sergey V. Kolomentsev +5 more
openalex +1 more source
A Fully Self‐Powered Digital Wearable System for the Auxiliary Treatment of Plantar Fasciitis
Advanced Science, EarlyView.This study reports a system‐level fully self‐powered digital wearable system (FS‐DWS) for the auxiliary treatment of plantar fasciitis. By integrating arch support, energy harvesting, wearable sensing, and machine learning‐driven closed‐loop visualized feedback, the system enables effective plantar pressure reduction and self‐powered, real‐time plantar
Jiacheng Hou +10 more
wiley +1 more source
The Diagnosis That Arrived Decades Late: Living Without and Then With Myhre Syndrome
American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.ABSTRACT Myhre syndrome (MIM #139210) is a rare multisystem disorder first described in 1981, characterized by short stature, neurodevelopmental delay, joint contractures, and cardiopulmonary complications. Its molecular basis, recurrent pathogenic variants in SMAD4, was not discovered until 2011. This narrative is based on a review of medical records,
Abdallah F. Elias
wiley +1 more source
Consideration of chronic pain and current prosthetic satisfaction in above knee amputees
طب جانباز, 2011 Background and purpose: Following limb loss, offering rehabilitation, prosthesis, assistive devices and training to restore function for amputee are really important. Chronic pain can cause patient’s psychological and physical limitations.
A. Yavari +4 more
doaj
A Neuromotor Device for Reducing Phantom Limb Pain in Individuals with Spinal Cord Injury
MATEC Web of Conferences, 2016 Phantom Limb Pain is a disorder that can be experienced by individuals after amputation or spinal cord injury. In spinal cord injury the paralysis or paresis is often bilateral, thus limiting the application of apparent movement as a therapeutic model ...
Cui Lei +2 more
doaj +1 more source
Construction of pathogenic Sec16a mutation mouse model using CRISPR/Cas9
Animal Models and Experimental Medicine, EarlyView.Yaqiang Hu et al. engineered a pathogenic Sec16a mutant mouse model using CRISPR/Cas9 technology. They observed that the Sec16a mutant mice displayed diminished learning and memory capabilities, along with a limb‐clasping phenotype upon tail suspension.
Yaqiang Hu +6 more
wiley +1 more source