Results 311 to 320 of about 1,837,770 (384)

Single‐Cell Dissection of the Biological Function and Molecular Features Underlying the Micropeptide LSMEM1 in Kidney

open access: yesAdvanced Science, EarlyView.
LSMEM1, an evolutionarily conserved micropeptide with extreme hydrophobicity (aliphatic index═113) and dynamic amphiphilicity (GRAVY═0.017), features a strong α‐helical transmembrane anchor (residues 64‐86). Single‐cell analysis reveals its critical role in renal lipid homeostasis.
Peimin Liu   +11 more
wiley   +1 more source

Nanofluid‐Enhanced Laser Lithotripsy Using Conducting Polymer Nanoparticles

open access: yesAdvanced Science, EarlyView.
Incorporating polymeric nanoparticles, PEDOT:PSS, with a high near‐infrared absorption coefficient into the fluid significantly enhances the dusting efficiency of Ho:YAG laser lithotripsy for kidney stone treatment. This approach, which leverages the control of light‐matter interactions, integrates seamlessly with the current laser lithotripsy workflow.
Qingsong Fan   +10 more
wiley   +1 more source

Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice

open access: yesAdvanced Science, EarlyView.
Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan   +9 more
wiley   +1 more source

Auditory Hair Cell Mechanotransduction Channels Dynamically Shape the Mechanical Properties of Their Membrane Environment

open access: yesAdvanced Science, EarlyView.
This work shows, for the first time, that the stereocilia membrane in cochlear hair cells is dynamically regulated by the mechanotransduction channel to impact the membrane mechanical properties. This work provides direct evidence that the opening and closing associated with the MET channel is regulating the membrane viscosity suggesting that the MET ...
Shefin Sam George, Anthony J. Ricci
wiley   +1 more source

Changes in pain and prosthesis wear following transfemoral osseointegration combined with sciatic nerve RPNI. [PDF]

open access: yesOTA Int
Bonvillain KW   +6 more
europepmc   +1 more source

Home - About - Disclaimer - Privacy