Results 91 to 100 of about 2,224,916 (342)

The pharmaceutical distribution chain in the European Union: structure and impact on pharmaceutical prices [PDF]

, 2011
In an environment characterised by fragmentation in the market structure of wholesale and retail entities, significant diversity in terms of remuneration schemes as well as regulations pertaining to operational features of wholesale and retail entities ...
Kanavos, Panos, Schurer, Willemien, Vogler, Sabine   +2 more
core  

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

FEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart, Haley L. Zubyk, Michelle Ogrodnik, Caitlin E. Mullarkey, Felicia Vulcu   +4 more
wiley   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

The Dynamics of Knowledge Accumulation, Regulation and Appropriability in the Pharma-Biotech Sector: Policy Issues [PDF]

, 2006
Discussion of reasons for regulation in the pharmaceutical ...
Dosi, Giovanni, Mazzucato, Mariana, Orsenigo, Luigi   +2 more
core  

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Marine yeast isolation and industrial application [PDF]

, 2014
Over the last century, terrestrial yeasts have been widely used in various industries, such as baking, brewing, wine, bioethanol and pharmaceutical protein production. However, only little attention has been given to marine yeasts. Recent research showed
Abdelrahman Saleh Zaky, Agnihotri, Amornrattanapan, Apte, Baheri, Bankar, Beuchat, Bharathi, Bondesson, Boretsky, Bowen, Buhagiar, Chandel, Chen, Chenyu Du, Chi, Chi, Chi, Chi, Chi, Chi, Cong, Connell, Cooper, Dinesh, Du, Duarte, Faiura, Fell, Gao, Gao, Gen, Gill, Gregory A. Tucker, Gupta, Hernandez-Saavedra, Hernandez-Saavedra, Higuera-Ciapara, Jain, Jannasch, Jarvis, Kathiresan, Katre, Khambhaty, King, Kodama, Kohlmeyer, Kutty, Leathers, Li, Li, Li, Li, Li, Libkind, Limtong, Lin, Liu, Liu, Loureiro, Masuda, Murugappan, Nagahama, Neuman, Obara, Oswal, Pandey, Peng, Peng, Pensupa, Ramirez-Orozco, Renshaw, Saravanakumar, Sarkar, Sarlin, Senthilraja, Stahmann, Subramanian, Thomson, Turkiewicz, Urano, Ushakumari, Wang, Wang, Wang, Watson, Wickerham, Winkelmann, Wu, Yanagisawa, Zakaria Yehia Daw, Zhang, Zhang, Zhang   +93 more
core   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

High efficient catalytic degradation of tetracycline and ibuprofen using visible light driven novel Cu/Bi2Ti2O7/rGO nanocomposite::Kinetics, intermediates and mechanism [PDF]

, 2019
The photoexcited charge carriers trapping was an effective way to generate a large number of active species like O-2(center dot-) and (OH)-O-center dot radicals to oxidize pharmaceutical molecules.
Acevedo, R., Anbarasan, P.M., Gkanas, Evangelos, Priyadharsan, A., Shanavas, S.   +4 more
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source