Results 31 to 40 of about 969,568 (244)
International Journal of Informatics, Information System and Computer Engineering, 2023 The pharmaceutical sector has to deal with issues like high costs, difficult diseases, and the demand for tailored therapy. The transformational potential of AI, 3D printing, and nanomedicine is examined in this paper.
Biplov Paneru, Bishwash Paneru
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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Nanomaterials, 2019 Innovative solutions using biopolymer-based materials made of several constituents seems to be particularly attractive for packaging in biomedical and pharmaceutical applications.
Jolanta Wróblewska-Krepsztul +3 more
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Food Bioengineering, 2023 Medicinal plants are an integral element of human society's effort to battle illness. Terminalia chebula Retz. (Haritaki) is known in China as the “King of Medicine” and is usually at the top of the list of “Ayurvedic Material Medica” due to its ...
Avinash K. Jha, Nandan Sit
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FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
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Open Data for Research and Strategic Monitoring in the Pharmaceutical and Biotech Industry
Data Science Journal, 2017 Open data is considered the new oil. As oil can be used to produce fertilisers, pesticides, lubricants, plastics and many other derivatives, so data is considered the commodity to use and re-use to create value.
Baldissera Giovani
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Indonesian Journal of Innovation and Applied Sciences, 2023 Malaria is a significant global health burden, particularly in regions with limited healthcare resources. Pharmaceutical interventions, specifically artemisinin-based combination therapies (ACTs), have long been the mainstay of malaria treatment due to ...
Abayomi Alade
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FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
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Mechanistic Research for the Student or Educator (Part II of II)
Frontiers in Pharmacology, 2022 This two-part series describes how to test hypotheses on molecular mechanisms that underlie biological phenomena, using preclinical drug testing as a simplified example.
Rehana K. Leak, James B. Schreiber
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