Results 111 to 120 of about 120,949 (295)

The Taiwanese health care system under efficiency scrutiny [PDF]

open access: yes
This thesis describes the status quo of the Taiwanese health care system in the year 2000, 5 years after the reforms, analyses the economic efficiency of single components of the new health care system and searches for possible solutions to solve ...
Schreyögg, Jonas
core  

Heme‐NO Dilates Arteries via Mobilization of NO Moieties From an Intracellular NO Store Within Vascular Smooth Muscle Cells

open access: yesAdvanced Science, EarlyView.
Nitrosyl heme emerges as an extracellular nitrodilator that dilates arteries without crossing the cell membrane. Instead, heme‐NO mobilizes NO moieties from a preformed intracellular NO store within vascular smooth muscle, providing both functional and chemical evidence for the NANOS model, revealing a previously unrecognized mechanism of arterial ...
Taiming Liu   +9 more
wiley   +1 more source

Patents, Public-Private Partnerships or Prizes – How should we support pharmaceutical innovation? [PDF]

open access: yes
The question as to how society should support pharmaceutical (‘pharma’) innovation is both pertinent and timely: Pharma drugs are an integral component of modern health care and hold the promise to treat more effectively various debilitating health ...
Paul Grootendorst
core  

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto   +20 more
wiley   +1 more source

Efficacy of Ciprofloxacin in Treating Gram-Negative Infections: Does Obesity Matter?

open access: yesPharmacy
Background: Obesity is considered a health issue associated with increased morbidity and a risk factor for multiple conditions, such as type 2 diabetes, cardiovascular diseases and infections.
Sultan Alotaibi   +7 more
doaj   +1 more source

Electrical Stimulation Directs Formation of Perfused Vasculature in Engineered Tissues

open access: yesAdvanced Science, EarlyView.
Electrical stimulation (ESTIM) enhances vasculature formation in engineered human tissues. In 3D endothelial‐fibroblast constructs, conditioning with ESTIM promotes the formation of dense and highly branched networks that rapidly anastomose with mouse vasculature when implanted in vivo. Vessels formed under ESTIM are importantly functionally perfusable.
Katarzyna A. Grzelak   +6 more
wiley   +1 more source

Real-World Experience of L-Glutamine in Sickle Cell Disease: A Retrospective Observational Study

open access: yesPharmacy
Sickle cell disease (SCD) affects millions globally, with approximately 0.26% of the Saudi population impacted. Despite standard treatments, patients frequently experience vaso-occlusive crises (VOCs). This retrospective observational study evaluated the
Shouq Turkistani   +6 more
doaj   +1 more source

Current views of community and hospital pharmacists on pharmaceutical care services in the United Arab Emirates: A mixed methodological study. [PDF]

open access: yesF1000Res, 2022
Kharaba Z   +8 more
europepmc   +1 more source

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