Results 181 to 190 of about 3,606,854 (303)

Chiral Nanoparticles Suppress Inflammatory Infiltration to Promote Extracellular Matrix Remodeling for Ectopia Lentis Therapy

Advanced Science, EarlyView.
L‐cysteine‐configured chiral polyurethane nanoparticles suppress ocular inflammation and reduce extracellular matrix (ECM) degradation in ectopia lentis by regulating macrophages polarization and inhibiting nuclear factor kappa B signaling pathway. By promoting zonular fiber‐associated protein restoration and tissue repair, this minimally invasive ...
Yinuo Wen, Yan Yang, Haihan Gao, Yan Liu, Xinyue Wang, Linghao Song, Ruohong Li, Ao Miao, Jie Xu, Zhennan Zhao, Dan Li, Shenjie Peng, Linzhao Li, Min Zhang, Yonghang Liu, Liren Wang, Tianhui Chen, Yongxiang Jiang   +17 more
wiley   +1 more source

Recent Advances in Mitochondrial Pyruvate Carrier Inhibitors

Pharmaceutical Fronts
Yilei Huang, Han Zhang, Xinyan Peng, Qingwei Zhang   +3 more
doaj   +1 more source

Digital interactions with the pharmaceutical industry: a qualitative focus group study on the perspectives of rheumatology care providers in Germany. [PDF]

BMC Rheumatol
May S, Jeleskovic-Öztürk A, Meisberger H, Stangel F, Boy K, Ohm N, Nordmann G, Darkow R, Knitza J, Muehlensiepen F.   +9 more
europepmc   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

An Improved Synthesis Process of Ricolinostat: The First Orally Selective HDAC6 Inhibitor

Pharmaceutical Fronts
Mengfei Wang, Niubing Sun, Qiushi Chen, Qingwei Zhang   +3 more
doaj   +1 more source

A lightweight large language model for regulatory affairs translation in pharmaceutical industry. [PDF]

Sci Rep
Chen T, Mo H, Wang T, Jiang C, Liu Z, Hou F, Gan J.   +6 more
europepmc   +1 more source

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

Advanced Science, EarlyView.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun, Ning Yu, Liang Yu, Xiaofen Tian, Yujia Ma, Yikuan Xie, Tao Wang, Chao Ma   +7 more
wiley   +1 more source

Evaluation of Corporate Social Responsibility Practices in the Turkish Pharmaceutical Industry. [PDF]

Turk J Pharm Sci
Azak Sungur S, Sözen Şahne B, Yeğenoğlu S.   +2 more
europepmc   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

A Novel Synthesis of 5-HT₄ Receptor Intestinal-Restrictive Bivalent Agonist: SIPI11588

Pharmaceutical Fronts
Linjie Zhang, Wenbo Zhang, Kunfan Zhang, Zixue Zhang, Guan Wang, Feng Ni   +5 more
doaj   +1 more source