Results 91 to 100 of about 105,036 (275)
Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes
FEBS Open Bio, EarlyView.We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde +3 more
wiley +1 more source
Accordo trips, brevetti e resistenze interne in India: uno scenario frastagliato
Kervan. International Journal of Afro-Asiatic Studies, 2016 This paper deals with the “difficult relationship” between India and pharmaceutical patents. Throughout the article, the strictly juridical dimension of the problem is let on the background.
Matteo Dragoni
doaj +1 more source
Strategic Under-utilization of Patents and Entry Deterrence: The Case of Pharmaceutical Industry [PDF]
This paper seeks to explain why some pharmaceutical companies are observed to withdraw their products before patents are expired and simultaneously introduce new patented (competing) products.
Dutta, Arijita +2 more
core +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
The Impact of Exempting the Pharmaceutical Industry from Patent Reviews [PDF]
, 2015 This paper analyzes the impact of an amendment to Senate Bill 1137, offered by Senator Thomas Tillis, which would exempt patents related to pharmaceuticals and biological products from the Inter Partes Review (IPR) process.
Dean Baker
core
FEBS Open Bio, EarlyView.Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda +12 more
wiley +1 more source
The Promising Viral Threat to Bacterial Resistance: The Uncertain Patentability of Phage Therapeutics and the Necessity of Alternative Incentives [PDF]
, 2014 Bacteriophages, or “phages,” are a category of highly adept and adaptable viruses that can infect and kill bacteria. With concerns over the burgeoning antibiotic-resistance crisis looming in recent years, scientists and policymakers have expressed a ...
Todd, Kelly
core +1 more source
Just how difficult can it be counting up R&D funding for emerging technologies (and is tech mining with proxy measures going to be any better?) [PDF]
, 2013 Decision makers considering policy or strategy related to the development of emerging technologies expect high quality data on the support for different technological options. A natural starting point would be R&D funding statistics.
Anon +22 more
core +1 more source
Aging and Cancer, EarlyView.Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath +3 more
wiley +1 more source
MAPPING OF PATENTS OF ORAL DISINTEGRATION PHARMACEUTICAL FORMS
Revista INGI, 2018 Formas farmacêuticas que atuam por desintegração na cavidade oral constituem uma importante forma de administração de fármacos, principalmente para setores pediátricos e geriátricos.
Thaís de Oliveira Costa +2 more
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