Results 101 to 110 of about 5,230,993 (373)

Just how difficult can it be counting up R&D funding for emerging technologies (and is tech mining with proxy measures going to be any better?) [PDF]

, 2013
Decision makers considering policy or strategy related to the development of emerging technologies expect high quality data on the support for different technological options. A natural starting point would be R&D funding statistics.
Anon, Archibuigi D., Augsdorfer P., Bijker W. E., Bowker G., Freeman C., Headrick D., Jaffe A. B., Josh Siepel, Martin P., Matthews K., Michael M. Hopkins, Morgan Jones M., NESTA, Nicholaisen J., Nuffield Council on Bioethics, OECD, OECD. 2009, Porter T., Rafols I., Rosenberg N., Searle J., Veugelers R.   +22 more
core   +1 more source

Scientific basis of the development and standardization of herbal medicines

Регуляторные исследования и экспертиза лекарственных средств, 2018
The present paper conceptually considers scientific approaches to standardization of starting materials of herbal origin and herbal medicinal products.
I. A. Samylina, V. A. Kurkin, G. P. Yakovlev   +2 more
doaj  

Co‐overexpression of the caloric restriction‐induced mitochondrial factors PGC‐1α and MIPEP upregulates Phospho1 expression in adipocytes

FEBS Open Bio, EarlyView.
Caloric restriction that extends lifespan induces the expression of PGC‐1α and MIPEP in white adipose tissue. In this study, co‐overexpression of Pgc‐1α and Mipep upregulated the gene expression of PHOSPHO1. These findings provide new insights into mitochondria‐related mechanisms underlying the effects of caloric restriction in adipocytes.
Mamiko Ishimatsu, Kanari Taki, Asuka Hayami, Komachi Kato, Yuka Nozaki, Yuhei Mizunoe, Takumi Narita, Ryoichi Mori, Yoshikazu Higami, Masaki Kobayashi   +9 more
wiley   +1 more source

Determining the pharmacological potential and biological role of linear pseudoscorpion toxins via functional profiling

iScience
Summary: Arthropod venoms contain bioactive molecules attractive for biomedical applications. However, few of these have been isolated, and only a tiny number has been characterized.
Pelin Erkoc, Susanne Schiffmann, Thomas Ulshöfer, Marina Henke, Michael Marner, Jonas Krämer, Reinhard Predel, Till F. Schäberle, Sabine Hurka, Ludwig Dersch, Andreas Vilcinskas, Robert Fürst, Tim Lüddecke   +12 more
doaj  

Beyond p‐values: Assessing clinical significance in acupuncture research

Advanced Chinese Medicine, EarlyView.
Abstract In acupuncture randomized controlled trials (RCTs), the proper interpretation of results requires a thorough understanding of key statistical concepts such as p‐value, effect size, and the minimal clinically important difference (MCID). This paper explores the relationships among these metrics and their implications for assessing the clinical ...
Changzhen Gong
wiley   +1 more source

Dendrimer entrapped microsponge gel of dithranol for effective topical treatment

Heliyon, 2019
Dithranol is one of the important topical agents for the treatment of psoriasis, a chronic inflammatory skin disease with aberrant differentiation of keratinocytes.
Pushpendra Kumar Tripathi, Bapi Gorain, Hira Choudhury, Ayushi Srivastava, Prashant Kesharwani   +4 more
doaj  

Discontinuation of Immunotherapy in Patients With Relapsing Myelitis Without AQP4/MOG Antibodies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This study assesses the outcomes of immunotherapy discontinuation in patients with relapsing seronegative idiopathic myelitis (SIM), a condition that remains uninvestigated due to its rarity. We reviewed records from 77 patients with relapsing SIM at the National Cancer Center of Korea, focusing on 11 who discontinued treatment after a median ...
Ki Hoon Kim, You‐Ri Kang, Jae‐Won Hyun, Su‐Hyun Kim, Ho Jin Kim   +4 more
wiley   +1 more source

Geographic proximity and firm-university innovation linkages: evidence from Great Britain [PDF]

We investigate evidence for spatially mediated knowledge transfer from university research. We examine whether firms locate their R&D labs near universities, and whether those that do are more likely to co-operate with, or source knowledge from ...
Helen Simpson, Laura Abramovsky
core   +3 more sources

Glucosamine/L-lactide copolymers as potential carriers for the development of a sustained rifampicin release system using Mycobacterium smegmatis as a tuberculosis model

Heliyon, 2019
The present study aims at developing a new, ultrafine particle-based efficient antibiotic delivery system for the treatment of tuberculosis. The carrier material to make the rifampicin (RIF)-loaded particles is a low molecular weight star-shaped polymer ...
Jorge Ragusa, Daniela Gonzalez, Sumin Li, Sandra Noriega, Maciej Skotak, Gustavo Larsen   +5 more
doaj  

Phenotyping Healthcare Use 2–3 Decades Before the First Multiple Sclerosis Demyelinating Event

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Phenotype hospital, physician, and emergency department (ED) visits by diagnoses and specialty up to 29 years pre‐multiple sclerosis (MS) onset versus a matched population without MS. Methods We identified people with MS (PwMS) using population‐based administrative data from Ontario, Canada (1991–2020).
Helen Tremlett, Karl Everett, Colleen J. Maxwell, Feng Zhu, Ayesha Asaf, Ping Li, Kyla A. McKay, Yinshan Zhao, Ruth Ann Marrie   +8 more
wiley   +1 more source