Results 101 to 110 of about 1,040,359 (356)

Data Science in Pharmaceutical Industry

, 2020
Data Science demand from Medical Affairs (MA) functions in the pharmaceutical industry are exponentially increasing, where business cases around more modern execution of activities and strategic planning are becoming a reality. MA is still lagging in terms of implementing data science and big data technology in the current times, which means a ...
Pesqueira, A., Sousa, M. J., Rocha, Á., Sousa, M.   +3 more
openaire   +3 more sources

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

FEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao, Yunlong Li, Lihua Chen, Wenshuo Yang, Yong He, Ye Yang, Dengke Yin, Song Tan   +7 more
wiley   +1 more source

Proportionality between powder cohesion and unconfined yield strength from shear cell testing

Heliyon, 2019
From an analysis of the geometry of the yield locus and the Mohr's circle for determining unconfined yield strength (fc) in shear cell testing, it has been shown that powder cohesion is proportional to fc, where the proportionality constant is a function
David J. Sun, Changquan Calvin Sun
doaj   +1 more source

Geographic proximity and firm-university innovation linkages: evidence from Great Britain [PDF]

We investigate evidence for spatially mediated knowledge transfer from university research. We examine whether firms locate their R&D labs near universities, and whether those that do are more likely to co-operate with, or source knowledge from ...
Helen Simpson, Laura Abramovsky
core  

Just how difficult can it be counting up R&D funding for emerging technologies (and is tech mining with proxy measures going to be any better?) [PDF]

, 2013
Decision makers considering policy or strategy related to the development of emerging technologies expect high quality data on the support for different technological options. A natural starting point would be R&D funding statistics.
Anon, Archibuigi D., Augsdorfer P., Bijker W. E., Bowker G., Freeman C., Headrick D., Jaffe A. B., Josh Siepel, Martin P., Matthews K., Michael M. Hopkins, Morgan Jones M., NESTA, Nicholaisen J., Nuffield Council on Bioethics, OECD, OECD. 2009, Porter T., Rafols I., Rosenberg N., Searle J., Veugelers R.   +22 more
core   +1 more source

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Scientific basis of the development and standardization of herbal medicines

Регуляторные исследования и экспертиза лекарственных средств, 2018
The present paper conceptually considers scientific approaches to standardization of starting materials of herbal origin and herbal medicinal products.
I. A. Samylina, V. A. Kurkin, G. P. Yakovlev   +2 more
doaj  

The delivery of mRNA to colon inflammatory lesions by lipid-nano-particles containing environmentally-sensitive lipid-like materials with oleic acid scaffolds

Heliyon, 2018
An mRNA gene therapy represents a potentially promising therapeutic for curing inflammatory diseases. The transient nature of the gene expression of mRNA would be expected to be beneficial for avoiding undesired side effects.
Hiroki Tanaka, Ayaka Watanabe, Manami Konishi, Yuta Nakai, Hiroki Yoshioka, Tatsuya Ohkawara, Hiroshi Takeda, Hideyoshi Harashima, Hidetaka Akita   +8 more
doaj   +1 more source

Early Academis Science and the Birth of Industrial Research Laboratories in the U.S. Pharmaceutical Industry [PDF]

The establishment and growth of industrial research laboratories is one of the key organizational innovations affecting technological progress in the United States in the 20th century.
Jeffrey L. Furman, Megan MacGarvie
core  

Clinical Trials, Innovation and Approaches to Ambidexterity in Pharmaceutical Startup Companies [PDF]

, 2013
The author investigated how the clinical trial process affected innovation in phar- maceutical start-up firms. An inductive qualitative case study methodology was uti- lized to investigate 3 pharmaceutical start-up firms who were conducting late stage ...
Heikki, Sørum
core