Results 101 to 110 of about 1,067,890 (357)
Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
Scientific basis of the development and standardization of herbal medicines
Регуляторные исследования и экспертиза лекарственных средств, 2018 The present paper conceptually considers scientific approaches to standardization of starting materials of herbal origin and herbal medicinal products.
I. A. Samylina +2 more
doaj
Capitalizing Science: Public Knowledge into Pharmaceutical Assets
, 2023 Victor Roy
openalex +2 more sources
FEBS Open Bio, EarlyView.Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani +7 more
wiley +1 more source
Heliyon, 2018 An mRNA gene therapy represents a potentially promising therapeutic for curing inflammatory diseases. The transient nature of the gene expression of mRNA would be expected to be beneficial for avoiding undesired side effects.
Hiroki Tanaka +8 more
doaj +1 more source
Clinical Trials, Innovation and Approaches to Ambidexterity in Pharmaceutical Startup Companies [PDF]
, 2013 The author investigated how the clinical trial process affected innovation in phar- maceutical start-up firms. An inductive qualitative case study methodology was uti- lized to investigate 3 pharmaceutical start-up firms who were conducting late stage ...
Heikki, Sørum
core
FEBS Open Bio, EarlyView.Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani +7 more
wiley +1 more source
Heliyon, 2019 The anti-oxidant effects of melatonin and the immune-pineal axis are well established. However, how they play a role in the pathogenesis of neurodegenerative diseases is not well elucidated.
Nitya Beriwal +3 more
doaj +1 more source
Tailored Doses by Means of Semi-Solid Extrusion-Based 3D Printing : A Study in Pharmaceutical Sciences [PDF]
, 2023 Monaco, Erica
openalex
FEBS Open Bio, EarlyView.This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart +4 more
wiley +1 more source