Results 121 to 130 of about 1,040,359 (356)
Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
Heliyon, 2019 Introduction: A considerable part of old people suffer from Chronic Cerebral Hypoperfusion (CCH) in their long lives but have no way to change. The Modified Dioscorea Pills (MDP), a Chinese compound herbal prescription, has good clinical efficacy for CCH
H.B. Li
doaj +1 more source
Card games are effective tools to enhance foundation year health and safety inductions
FEBS Open Bio, EarlyView.A series of three card games was developed to actively deliver health and safety education to foundation year students. Most students reported positive responses regarding their enjoyment (89.9 %) and learning (74.7 %) from all games evaluated. Data revealed significant improvements in health and safety knowledge (P < 0.0001).
Rumana Rafiq +4 more
wiley +1 more source
Heliyon, 2018 Background: The antiepileptic lamotrigine is approved for maintenance treatment of bipolar disorder and augmentation therapy in treatment-resistant depression.
Simona Scheggi +4 more
doaj +1 more source
The Future of Drug Development: The Economics of Pharmacogenomics [PDF]
This paper models how the evolving field of pharmacogenomics (PG), which is the science of using genomic markers to predict drug response, may impact drug development times, attrition rates, costs, and the future returns to research and development (R&D).
John A. Vernon, W. Keener Hughen
core
The Dynamics of Knowledge Accumulation, Regulation and Appropriability in the Pharma-Biotech Sector: Policy Issues [PDF]
, 2006 Discussion of reasons for regulation in the pharmaceutical ...
Dosi, Giovanni +2 more
core
FEBS Open Bio, EarlyView.Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani +7 more
wiley +1 more source
КЛІНІЧНІ АСПЕКТИ КОНТРОЛЮ ПОБІЧНИХ ЕФЕКТІВ ЛІКАРСЬКИХ ЗАСОБІВ [PDF]
, 2016 Проблема побічної дії лікарських засобів (ПД ЛЗ) привертає все більшу увагу, набуваючи медико-соціальне значення у зв'язку з наростаючим потоком надходження нових медикаментів і збільшенням числа ускладнень при їх використанні.
Білай, І.М. +3 more
core +1 more source
FEBS Open Bio, EarlyView.This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart +4 more
wiley +1 more source
Product recalls: The effects of industry, recall strategy and hazard, on shareholder wealth [PDF]
, 2018 The purpose of this paper is to provide insights into the effects of product recalls on shareholder wealth of manufacturing firms in different supply chains.
Bastl, Marko +3 more
core +1 more source