Results 301 to 310 of about 1,040,359 (356)

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source

One-step degradation of 4 classes of β-lactam using β-lactamase enzyme cocktail. [PDF]

Sci Rep
Lin J, Wang T, Zhou Y, Cheng T, Liu H, Chen X, Luo W, Liu Q, Chu Y, Wang X, Xie F, Sha J, Song T.   +12 more
europepmc   +1 more source

Indobufen alleviates apoptosis by the PI3K/Akt/eNOS pathway in myocardial ischemia‒reperfusion (I/R) injury. [PDF]

Sci Rep
Hou K, Pan K, Xu D, Li Y, Cao H.
europepmc   +1 more source

Driving health transformation: big pharma's innovation labs revolution. [PDF]

Health Res Policy Syst
Peralta G, Sánchez B.
europepmc   +1 more source

Analysis of the Effect of the Tablet Matrix on the Polymorphism of Ibuprofen, Naproxen, and Naproxen Sodium in Commercially Available Pharmaceutical Formulations. [PDF]

Methods Protoc
Leyk E, Środa M, Maślanka G, Nowaczyk P, Orzołek A, Grodzka H, Kurek A, Knut O, Michalak J, Płachciak J, Plenis A.   +10 more
europepmc   +1 more source

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Pharmaceutical Sciences—1968. A Literature Review of Pharmaceutics

Journal of Pharmaceutical Sciences, 1969
This review of the literature represents a comprehensive cross section of the research and development efforts in various selected disciplines of the pharmaceutical sciences. It is the ninth annual survey in the series (1–8). To compile it, numerous periodicals and selected sections of Chemical Abstracts were abstracted.
Peter D. Bernardo, Emanuel J. Russo
openaire   +3 more sources

Information Intervention in the Pharmaceutical Sciences

Medical Reference Services Quarterly, 2012
Professional guidelines state that higher-order thinking skills are a desirable outcome of pharmacy education. In this context, courses in pharmaceutics at the University of Southern California are taught in a learner-centered manner that requires use of chemical reference sources and interpretation of physicochemical information for drug molecules. To
Rebecca M. Romero, Amy J. Chatfield, Ian S. Haworth   +2 more
openaire   +3 more sources

Pharmaceutical sciences in 2020

Nature Reviews Drug Discovery, 2010
By 2020, current scientific, business and social challenges and developments — such as R&D productivity, increased regulatory stringency and ageing populations — are likely to substantially affect many aspects of the pharmaceutical sciences. Here, we present four potential future scenarios based on discussions with experts in the pharmaceutical ...
Hubert G. M. Leufkens, Kamal K. Midha, Vinod P. Shah, Pieter Stolk, Daan J.A. Crommelin, Luc Besançon   +5 more
openaire   +2 more sources