Results 201 to 210 of about 25,044 (295)

PMO's protective wrap: Unraveling its surfactant-mediated stabilization for next-generation antisense therapies. [PDF]

Mol Ther Nucleic Acids
Sharma SN, Gupta A, Sinha S.
europepmc   +1 more source

Neurofilament light chain as in vitro and clinical biomarker of vincristine‐induced peripheral neuropathy

British Journal of Clinical Pharmacology, EarlyView.
Aims Vincristine‐induced peripheral neuropathy (VIPN) is a common side effect in children and adolescents treated with vincristine. Assessing VIPN, especially in young children, is challenging due to a lack of sensitive tools. This limits our understanding of the nature and risk factors of VIPN. This study aimed to investigate neurofilament light chain
Peter Erik Lotko Pontoppidan, Christian Bach Vase, Christina Mortensen, Liv Andres‐Jensen, Dorte Aalund Olsen, Jonna Skov Madsen, Kjeld Schmiegelow, Rene Mathiasen, Tore Bjerregaard Stage   +8 more
wiley   +1 more source

The missing thread of One Health efforts: improper drug disposal as an overlooked driver of antimicrobial resistance. [PDF]

mSphere
Mukhopadhyay S, Debnath F, Chakraborty D.   +2 more
europepmc   +1 more source

Lack of improvement after short‐term topical antistaphylococcal endolysin SA.100 therapy in patients with mild‐to‐moderate atopic dermatitis: Results from a randomized, vehicle‐controlled trial

British Journal of Clinical Pharmacology, EarlyView.
Abstract Atopic dermatitis (AD) is a chronic immune‐mediated inflammatory skin disease. An overgrowth of Staphylococcus aureus (S. aureus) and decreased microbial diversity is apparent in 70%–90% of AD patients. SA.100 is a recombinant endolysin targeting S. aureus that might be a novel treatment for patients with mild‐to‐moderate AD.
Laura W. J. van der Meulen, Menthe E. Bergmans, Salma Assil, Ismahaan Abdisalaam, Rianne Rijneveld, Erica S. Klaassen, Alexa J. Tibboel, Thorsten Brach, Bjorn L. Herpers, Johan Frieling, Benthe Freyee, Karin Platenkamp, Mariette E. van Poelgeest, Robert Rissmann, Martijn B. A. van Doorn, Tessa Niemeyer – van der Kolk   +15 more
wiley   +1 more source

S. aureus colonization and clinical symptoms remain stable upon topical XZ.700 treatment: Results of a double‐blind randomized clinical trial in patients with mild to moderate atopic dermatitis

British Journal of Clinical Pharmacology, EarlyView.
Aim Recovering dysbiosis may improve atopic dermatitis (AD) symptoms. XZ.700 is a recombinant chimeric endolysin that specifically targets Staphylococcus aureus and could be a new treatment option for patients with AD. The aim of this first‐in‐human study was to evaluate the safety, tolerability and efficacy of topical XZ.700 and explore the ...
Laura W. J. van der Meulen, Menthe E. Bergmans, Salma Assil, Naomi Klarenbeek, Marieke L. de Kam, Alexa J. Tibboel, Thorsten Brach, Bjorn L. Herpers, Johan Frieling, Vincent de Jong, Benthe Freyee, Martijn B. A. van Doorn, Robert Rissmann, Tessa Niemeyer–van der Kolk   +13 more
wiley   +1 more source

Bioengineering and nephrology converge to drive kidney-targeted therapies. [PDF]

Nat Rev Nephrol
Patel V, Chung EJ.
europepmc   +1 more source

Pharmacokinetic Assessment of Atazanavir and Favipiravir Following Echinacea Supplementation: A Controlled Herb–Drug Interaction Investigation

Biopharmaceutics &Drug Disposition, EarlyView.
Pharmacokinetic interactions between Echinacea and two antiviral drugs, favipiravir and atazanavir, were assessed in rats. The findings suggest that Echinacea does not significantly affect the pharmacokinetics of favipiravir and atazanavir. These results provide preliminary evidence that concurrent use of Echinacea with these antiviral drugs may be ...
Siva Nageswara Rao Gajula, Jeevan Sai Kallam, Aarika Kanukolanu, Ganesh Korada, Lakshmi Vineela Nalla   +4 more
wiley   +1 more source

Rational design of next-generation vaccine adjuvants: From molecular mechanisms to hybrid delivery platforms. [PDF]

Hum Vaccin Immunother
Zhao Y, Li J, Chen J, Yang C, Tao J, Zhu R.   +5 more
europepmc   +1 more source

High‐performance tetrahedral palladium nanocatalyst for microwave‐assisted organic synthesis

Bulletin of the Korean Chemical Society, EarlyView.
Tetrahedral palladium nanoparticles anchored on graphene sheets (T‐Pd/graphene) were synthesized through a solvent‐free process involving thermal decomposition in an environment rich in carbon monoxide at elevated temperatures and have high catalytic activity for organic chemistry reactions. Abstract Palladium is widely recognized for its effectiveness
Dicky Annas, Kyung Hee Oh, Muthuchamy Nallal, Hack‐Keun Lee, Shin Wook Kang, Kwonho Jang, Jun‐Hyun Kim, Hyun Sung Kim, Ji Chan Park, Kang Hyun Park   +9 more
wiley   +1 more source

Exosomes: Redefining intercellular communication and the future of translational medicine. [PDF]

Bioimpacts
Adibkia K, Mahmoudi Gharehbaba A.
europepmc   +1 more source