Results 21 to 30 of about 534,439 (293)

Assessing the exposure risk and impacts of pharmaceuticals in the environment on individuals and ecosystems [PDF]

, 2013
Copyright @ 2013 The authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited.The
Boxall, A.B.A., Cuthbert, Richard, Shore, R.F., Arnold, KE, Brown, A.R., Naidoo, V, Boxall, AB, Gaw, Sally, Taggart, MA, Thompson, HM, Naidoo, V., Metcalfe, CD, Arnold, Kathryn E., Metcalfe, Chis D., Cuthbert, R.J., Gaw, S, Taggart, M.A., Thompson, H.M., Madden, J.C., Smits, JE, Hutchinson, Thomas H., Jobling, S, Jobling, Susan, Brown, AR, Jobling, S., Madden, Judith C., Thompson, Helen M., Cuthbert, RJ, Brown, A. Ross, Arnold, K.E., Taggart, Mark A., Shore, RF, Cuthbert, Richard J., Smits, J.E., Naidoo, Vinny, Shore, Richard F., Boxall, ABA, Metcalfe, Chris D., Gaw, S., Smits, Judit E., Madden, JC, Metcalfe, C.D., Boxall, Alistair B.A., Hutchinson, T.H., Hutchinson, TH   +44 more
core   +1 more source

Rapid TCR:Epitope Ranker (RAPTER): a primary human T cell reactivity screening assay pairing epitope and TCR at single cell resolution

Scientific Reports, 2023
Identifying epitopes that T cells respond to is critical for understanding T cell-mediated immunity. Traditional multimer and other single cell assays often require large blood volumes and/or expensive HLA-specific reagents and provide limited phenotypic
Raquel P. Deering, Lili Blumenberg, Lianjie Li, Ankur Dhanik, Se Jeong, Stephane Pourpe, Hang Song, Lauren Boucher, Shoba Ragunathan, Yanxia Li, Maggie Zhong, Jessica Kuhnert, Christina Adler, Peter Hawkins, Namita T. Gupta, Michael Moore, Min Ni, Johanna Hansen, Yi Wei, Gavin Thurston   +19 more
doaj   +1 more source

INO-4800 DNA vaccine induces neutralizing antibodies and T cell activity against global SARS-CoV-2 variants

npj Vaccines, 2021
Global surveillance has identified emerging SARS-CoV-2 variants of concern (VOC) associated with broadened host specificity, pathogenicity, and immune evasion to vaccine-induced immunity. Here we compared humoral and cellular responses against SARS-CoV-2
Viviane M. Andrade, Aaron Christensen-Quick, Joseph Agnes, Jared Tur, Charles Reed, Richa Kalia, Idania Marrero, Dustin Elwood, Katherine Schultheis, Mansi Purwar, Emma Reuschel, Trevor McMullan, Patrick Pezzoli, Kim Kraynyak, Albert Sylvester, Mammen P. Mammen, Pablo Tebas, J. Joseph Kim, David B. Weiner, Trevor R. F. Smith, Stephanie J. Ramos, Laurent M. Humeau, Jean D. Boyer, Kate E. Broderick   +23 more
doaj   +1 more source

Immunogenicity of biologic therapies for migraine: a review of current evidence

The Journal of Headache and Pain, 2021
Background Monoclonal antibodies (mAbs) targeting the calcitonin gene-related peptide (CGRP) pathway have been shown to be effective in migraine prevention. Eptinezumab, erenumab, fremanezumab, and galcanezumb have shown efficacy in clinical trials along
Joshua M. Cohen, Xiaoping Ning, Yoel Kessler, Michele Rasamoelisolo, Verena Ramirez Campos, Michael J. Seminerio, Lynda J. Krasenbaum, Honglue Shen, Jennifer Stratton   +8 more
doaj   +1 more source

UPTAKE OF PHARMACEUTICALS AND PERSONAL CARE PRODUCTS FROM SEDIMENTS INTO AQUATIC ORGANISMS [PDF]

, 2013
Over the past fifteen years there has been increasing interest in the environmental occurrence, fate and effects of substances used as pharmaceuticals or personal care products.
Karlsson, Maja V
core   +5 more sources

RSPO3 antagonism inhibits growth and tumorigenicity in colorectal tumors harboring common Wnt pathway mutations

Scientific Reports, 2017
Activating mutations in the Wnt pathway are a characteristic feature of colorectal cancer (CRC). The R-spondin (RSPO) family is a group of secreted proteins that enhance Wnt signaling and RSPO2 and RSPO3 gene fusions have been reported in CRC.
Marcus M. Fischer, V. Pete Yeung, Fiore Cattaruzza, Rajaa Hussein, Wan-Ching Yen, Christopher Murriel, James W. Evans, Gilbert O’Young, Alayne L. Brunner, Min Wang, Jennifer Cain, Belinda Cancilla, Ann Kapoun, Timothy Hoey   +13 more
doaj   +1 more source

Rare loss of function variants in the hepatokine gene INHBE protect from abdominal obesity

Nature Communications, 2022
Abdominal fat has been shown to increase cardiometabolic disease risk. In this study, the authors report that loss-of-function variants in the gene INHBE associate with lower BMI-adjusted waist-to-hip ratio, a surrogate measure of abdominal fat.
Aimee M. Deaton, Aditi Dubey, Lucas D. Ward, Peter Dornbos, Jason Flannick, AMP-T2D-GENES Consortium, Elaine Yee, Simina Ticau, Leila Noetzli, Margaret M. Parker, Rachel A. Hoffing, Carissa Willis, Mollie E. Plekan, Aaron M. Holleman, Gregory Hinkle, Kevin Fitzgerald, Akshay K. Vaishnaw, Paul Nioi   +17 more
doaj   +1 more source

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity

Nature Communications, 2018
A subset of chemically-modified siRNAs conjugated to trivalent GalNAc may fail during nonclinical development due to rat hepatotoxicity. Here, the authors show that hepatotoxicity may be accounted for by microRNA-like off-target effects of siRNA and can ...
Maja M. Janas, Mark K. Schlegel, Carole E. Harbison, Vedat O. Yilmaz, Yongfeng Jiang, Rubina Parmar, Ivan Zlatev, Adam Castoreno, Huilei Xu, Svetlana Shulga-Morskaya, Kallanthottathil G. Rajeev, Muthiah Manoharan, Natalie D. Keirstead, Martin A. Maier, Vasant Jadhav   +14 more
doaj   +1 more source

Do pharmaceuticals displace local knowledge and use of medicinal plants? Estimates from a cross-sectional study in a rural indigenous community, Mexico [PDF]

, 2011
Researchers examining the relationships between traditional medicine and biomedicine have observed two conflicting tendencies. Some suggest that the use of biomedicine and biomedical concepts displaces the use of traditional medicine and medical beliefs.
Heinrich, Michael, Reyes-Garcia, Victoria, Waldstein, Anna, Peter Giovannini, Waldsteinm, V, Giovannini, Peter, Reyes-Garcia, P, Victoria Reyes-García, Anna Waldstein, Michael Heinrich, Giovannini, P, Heinrich, M   +11 more
core   +1 more source