Results 81 to 90 of about 534,439 (293)

IL-33 expands plasma cells, disrupts germinal centers, and increases autoantibody production in mice

Nature Communications
IL-33 is an inflammatory cytokine contributing to asthma, Chronic Obstructive Pulmonary Disease (COPD), and autoimmune diseases. Although recent studies suggest that IL-33 can induce the generation of autoantibodies, the role of IL-33 on B cell ...
Eva Conde, Seblewongel Asrat, Andrea Vecchione, Kaitlyn Gayvert, Paulina Pedraza, Carley Tasker, Sharon Huang, Dmitry Yarilin, Dylan Birchard, Li-Hong Ben, Wei Keat Lim, Andrew J. Murphy, Matthew A. Sleeman, Andre Limnander, Jamie M. Orengo   +14 more
doaj   +1 more source

Myostatin and activin blockade by engineered follistatin results in hypertrophy and improves dystrophic pathology in mdx mouse more than myostatin blockade alone

Skeletal Muscle, 2018
Background Myostatin antagonists are being developed as therapies for Duchenne muscular dystrophy due to their strong hypertrophic effects on skeletal muscle.
Andrea Iskenderian, Nan Liu, Qingwei Deng, Yan Huang, Chuan Shen, Kathleen Palmieri, Robert Crooker, Dianna Lundberg, Niksa Kastrapeli, Brian Pescatore, Alla Romashko, John Dumas, Robert Comeau, Angela Norton, Jing Pan, Haojing Rong, Katayoun Derakhchan, David E. Ehmann   +17 more
doaj   +1 more source

Ultrafast visual detection of Streptococcus suis via HtpsC‐targeted LAMP–CRISPR–Cas12a coupled with lateral flow immunochromatography

FEBS Open Bio, EarlyView.
A rapid visual test combines DNA amplification, CRISPR–based target verification, and a lateral flow strip to detect Streptococcus suis. The assay gives results in about 45 min, reduces false‐positive interpretation, and does not require fluorescence equipment.
Liu‐xin Li, Miao Xin, Xiao‐wen Cui, Shi‐yin Yu, Fei Meng, Min Cao, Xiao‐hui Xiong, Yi‐chen Lu   +7 more
wiley   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

A nationwide student survey on biochemistry learning resources in Italy

FEBS Open Bio, EarlyView.
We conducted a survey among Italian university students to investigate their preferred study materials for biochemistry. We then analyzed the collected data to identify these materials. This information may be valuable to the Biochemistry educational community. The graphical abstract was created with Claude (Opus 5.5; Anthropic, 2026).
Anna Marabotti, Ivano Eberini, Maria Luisa Genova, Francesca Mensitieri, Francesco Malatesta   +4 more
wiley   +1 more source

GDF8 and activin A are the key negative regulators of muscle mass in postmenopausal females: a randomized phase I trial

Nature Communications
Evolutionary pressures to protect against food scarcity likely resulted in highly-conserved pathways designed to minimize energy expenditure, one of which involves the minimization of muscle mass; these mechanisms may be counter-productive in a modern ...
Dinko Gonzalez Trotter, Stephen Donahue, Chris Wynne, Shazia Ali, Prodromos Parasoglou, Anita Boyapati, Kusha Mohammadi, Bret J. Musser, Pretty Meier, Jason Mastaitis, Mark W. Sleeman, David J. Glass, Evelyn Gasparino, Jesus Trejos, John D. Davis, Boaz Hirshberg, Robert Pordy, George D. Yancopoulos, Gary A. Herman   +18 more
doaj   +1 more source

Investments in Pharmaceuticals Before and After TRIPS [PDF]

We examine the relationship between patent protection for pharmaceuticals and investment in development of new drugs. Patent protection has increased around the world as a consequence of the TRIPS Agreement, which specifies minimum levels of intellectual
Margaret Kyle, Anita McGahan
core  

Design and evaluation of FEBS Education and Training Academy module – Integrating generative artificial intelligence into life‐science education

FEBS Open Bio, EarlyView.
Life‐science educators from 14 countries redesigned their own course materials with generative AI in a three‐session, pedagogy‐first FEBS Education and Training Academy workshop built on PICRAT. Among 12 matched respondents, four more reported high confidence in each of five practical domains, and 10 of 13 reported implementing at least one idea ...
Zvonimir Mlinarić, Ali Burak Özkaya
wiley   +1 more source

Global Competitiveness in Pharmaceuticals: A European Perspective [PDF]

The report examines the competitive position of the European pharmaceutical companies and industries, and compares them with the pharmaceutical companies and industries in other parts of the world, particularly the US.
Gambardella, Alfonso, Pammolli, Fabio, Orsenigo, Luigi   +2 more
core  

Efficacy and safety of fasinumab in an NSAID-controlled study in patients with pain due to osteoarthritis of the knee or hip

BMC Musculoskeletal Disorders
Objective Osteoarthritis (OA) causes significant musculoskeletal pain. This study assessed the efficacy and safety of fasinumab, an investigational nerve growth factor inhibitor, in patients with moderate-to-severe OA pain of the knee/hip.
Stephen J. DiMartino, Haitao Gao, Simon Eng, Guillermo Valenzuela, Thomas Fuerst, Chetachi Emeremni, Tina Ho, Hazem E. Hassan, Kenneth C. Turner, John D. Davis, Souhil Zaim, Jesse Chao, Yamini Patel, Lillian Brener, Ngan Trinh, Garen Manvelian, Michael Fetell, Ned Braunstein, Gregory P. Geba, Paula Dakin   +19 more
doaj   +1 more source