Results 81 to 90 of about 71,068 (268)

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Exploring pharmacy provision of medication abortion pills in Nepal: a mixed-methods study of pharmacy workers’ knowledge and practices

Sexual and Reproductive Health Matters
In Nepal, pharmacists are legally permitted to dispense medication abortion drugs with a prescription but provision of mifepristone/misoprostol without a prescription is prohibited. However, one in five Nepalese women seeking medication abortion pills do
Nished Rijal, Angel M. Foster
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

An ideological playground? Changes in community pharmacy ownership – a case study from four Nordic and Baltic countries

Journal of Pharmaceutical Policy and Practice
The pharmacy systems have undergone fundamental changes in some Nordic and Baltic countries: Iceland, Norway, Sweden and Estonia. The political declared aims of the reforms have included increasing competition and/or effectiveness of the pharmacy market ...
Katri Hämeen-Anttila, Anna Birna Almarsdóttir, Daisy Volmer, Ingunn Björnsdottir, Sofia Kälvemark Sporrong   +4 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Supporting cancer screening uptake in South Asian women: the wise up to cancer public health intervention

Critical Public Health
British South Asian women’s uptake of cervical, breast, and bowel cancer screening is lower than the national average. ‘Wise up to cancer’ is a public health intervention, used with the general public, partly designed to increase cancer screening uptake.
Mel Haith-Cooper, Daisy Payne, Nisa Almas, Marcus Rattray, Halima Iqbal   +4 more
doaj   +1 more source

Implementing pharmacy-located HPV vaccination: findings from pilot projects in five U.S. states

Human Vaccines & Immunotherapeutics, 2019
Pharmacies are promising alternative settings for human papillomavirus (HPV) vaccination because of their population reach, convenience, and existing infrastructure for vaccine delivery.
William A. Calo, Parth D. Shah, Melissa B. Gilkey, Robin C. Vanderpool, Sarah Barden, William R. Doucette, Noel T. Brewer   +6 more
doaj   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Trends in adolescent and adult vaccination in pharmacy and medical settings in the United States, 2018–2024: a database study

Expert Review of Vaccines
Background Pharmacies can increase access to vaccines. This study aimed to describe trends in the proportion of adolescent and adult vaccinations administered in pharmacies in the United States from 2018 to 2024.Research design and methods This was a ...
Yi Zheng, Dong Wang, Ya-Ting Chen, Kunal Saxena, Goran Bencina, Amanda L. Eiden   +5 more
doaj   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source