Results 201 to 210 of about 347,518 (361)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Medication Management Strategies at Hospital Admission: A Systematic Review and Meta-Analysis. [PDF]

Clin Transl Sci
Emadi T, Yiu CH, Liu S, Tang D, Yeung K, Baysari M, Budgeon C, Carter S, Criddle D, Fleming C, Francis M, Grover C, Hawthorne A, Hawthorne D, Khlentzos A, Khlentzos J, Krogh L, McMillan F, Moles R, Nguyen K, Oldfield L, Packer A, Penm M, Pham L, Phillips K, Poon S, Ratnanayagam G, Rigby D, Sanfilippo F, Shakib S, Tan E, Van Dort B, Yates P, Yik J, Angley M, Elliott RA, Penm J.   +36 more
europepmc   +1 more source

The contribution of community pharmacy to improving the public’s health: summary report of the literature review 1990–2007 [PDF]

, 2009
Anderson, Claire, Armstrong, Miriam, Blenkinsopp, Alison   +2 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Responsible preoperative opioid use for hip or knee arthroplasty (OpioidHALT): a protocol for a randomised clinical trial of pharmacist-partnered opioid tapering prior to hip or knee arthroplasty. [PDF]

BMJ Open
Penm J, Liu S, Adie S, Ashton-James CE, Bailey KA, Brady B, Chaar B, Chen J, Descallar J, Englezos K, Genel F, Gillespie D, Gnjidic D, Hoang T, Jansson A, Jauregui KJ, Keehan M, Lin CC, Lintzeris N, Luckie K, Mathieson S, Moles RJ, Mulford J, Nealon L, O'Reilly CL, Page F, Patanwala AE, Penm M, Quirk R, Ratnanayagam G, Schaper F, Schneider CR, Sefton A, Si L, Stevens J, Sylvester K, Tan S, Tran C, Naylor JM.   +38 more
europepmc   +1 more source

Publishing by Pharmacists [PDF]

DICP, 1989
openaire   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Hospital Pharmacist in the Emergency Department

Iberoamerican Journal of Medicine, 2020
Yared González-Pérez, Carlos Sáiz de Rozas Aparicio   +1 more
doaj   +1 more source