Results 241 to 250 of about 93,887 (308)

Tolvaptan pharmacokinetics and pharmacodynamics in adolescents with autosomal dominant polycystic kidney disease. [PDF]

Eur J Pediatr
Shoaf SE, Sikes K.
europepmc   +1 more source

The Visual Predictive Check and Real‐World Data

Clinical Pharmacology &Therapeutics, EarlyView.
The visual predictive check (VPC) is a standard tool for assessing pharmacometric model suitability, producing visualizations that compare observed data with simulated data such that both model structure and model variability terms can be assessed. However, real‐world data commonly reflect clinical decision‐making that adapts therapy in response to ...
Jasmine H. Hughes, Martin Bergstrand, Ron J. Keizer   +2 more
wiley   +1 more source

Population Pharmacokinetic/Pharmacodynamic Modeling of Donidalorsen, an Antisense Oligonucleotide in Development for Prophylaxis of Hereditary Angioedema. [PDF]

CPT Pharmacometrics Syst Pharmacol
Diep JK, Liu M, Singh P, Dorow S, Cohn DM, Bordone L, Newman KB, Gao X.   +7 more
europepmc   +1 more source

First-in-human, phase 1 study of CM512, a TSLP/IL-13 bispecific antibody, in healthy volunteers: safety, tolerability, pharmacokinetics, pharmacodynamics, and immunogenicity. [PDF]

Front Immunol
Cheng Y, Liu Q, Li M, Xie Y, Men Y, He M, Wang H, Feng X, Zeng M, Zhang L, Chen B, Li J, Feng P.   +12 more
europepmc   +1 more source

Study of remimazolam besylate for general anaesthesia and population pharmacokinetics-pharmacodynamics in elderly, hepatic or renal-insufficient patients: a protocol for a multicentre randomised controlled trial in China. [PDF]

BMJ Open
Tang M, Zhu M, Chen G, Zhu T, Yin Q.
europepmc   +1 more source

Comparison of pharmacokinetics, pharmacodynamics, safety, and immunogenicity of a candidate biosimilar INTP23.1 with EU and US‑approved denosumab reference products in healthy adult men. [PDF]

Naunyn Schmiedebergs Arch Pharmacol
Fenwick S, Parekh V, Shah N, Patel R, Kale P, Kolte S.   +5 more
europepmc   +1 more source

From hype to hope: reanimating phage therapy through evidence-based multidisciplinarity. [PDF]

Nat Commun
Petrović-Fabijan A, Abedon ST.
europepmc   +1 more source

Gaps and paths forward in cancer pharmacology and translational research. [PDF]

Front Pharmacol
Hughes EA, Davenport LL, Zdyrski C, Pawlak A, Mochel JP, Douglass EF.   +5 more
europepmc   +1 more source

Genetic and nongenetic factors affecting vancomycin population pharmacokinetics and pharmacodynamics: A systematic review.

Indian J Pharmacol
Pradana DA, Marfianti E, Wibowo A.
europepmc   +1 more source