Results 51 to 60 of about 51,995 (213)

The health-related social costs of alcohol in Belgium [PDF]

, 2017
Background: Alcohol is associated with adverse health effects causing a considerable economic impact to society. A reliable estimate of this economic impact for Belgium is lacking. This is the aim of the study.
Annemans, Lieven, Lievens, Delfine, Putman, Koen, Vander Laenen, Freya, Verhaeghe, Nick   +4 more
core   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Issues for countries considering introducing the "fourth hurdle": The case of Hungary [PDF]

, 2004
Objectives: This study outlines the needs and current development of the "fourth hurdle" (i.e., requirement of effectiveness and cost-effectiveness data for drug coverage policy decisions) in Hungary, describes the legal background and seeks to address ...
Boncz, I, Drummond, M, Gulacsi, L
core   +1 more source

Paternal use of metformin and risk of major congenital malformations: A meta‐analysis of 4 studies

British Journal of Clinical Pharmacology, EarlyView.
Abstract Metformin is the first‐line drug for the treatment of Type 2 diabetes. In 2022, a Danish registry‐based study reported a 40% increased risk of major congenital malformations following paternal exposure during spermatogenesis. This raised widespread concern about the use of metformin in males of reproductive age.
Per Damkier, Marleen M. H. J. van Gelder, Krista F. Huybrechts, Lin‐Chieh Meng, Sonia Hernandez‐Diaz, Jan Nielsen, Bente M. Nørgård, Hedvig Nordeng   +7 more
wiley   +1 more source

A US hospital budget impact analysis of a skin closure system compared with standard of care in hip and knee arthroplasty. [PDF]

, 2018
Background: Medicare\u27s mandatory bundle for hip and knee arthroplasty necessitates provider accountability for quality and cost of care to 90 days, and wound closure may be a key area of consideration.
Ferko, Nicole, Flener, Jana, Gargiulo, Jeanine, Hogan, Andrew, Hollmann, Sarah, Post, Zachary D., Sadik, Kay, Wurzelbacher, Steven   +7 more
core   +1 more source

Analyzing differences in the costs of treatment across centers within economic evaluations [PDF]

, 2001
Objectives: Assessments of health technologies increasingly include economic evaluations conducted alongside clinical trials. One particular concern with economic evaluations conducted alongside clinical trials is the generalizability of results from one
Coyle, D, Drummond, M F
core   +1 more source

Financial Toxicity Associated with Biological Medicines: A Scoping Review

Clinical Pharmacology &Therapeutics, EarlyView.
Financial toxicity, defined as the economic burden experienced by patients due to medication and other healthcare costs and their consequences, such as material, psychosocial and behavioral effects, represents a significant concern for individuals receiving biological medicines.
Laura Sara Maria Saarukka, Kamilla Yamileva, Kari Linden, Anniina Simonen, Anna‐Riia Holmström   +4 more
wiley   +1 more source

When does NICE recommend the use of health technologies within a programme of evidence development? [PDF]

, 2013
This article is made available through the Brunel Open Access Publishing Fund. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in ...
A Briggs, A Towse, C Carbonneil, CJ McCabe, D Menon, Department of Health, Eldon Spackman, IA Dhalla, J Hutton, JiHee Youn, JJ Carlson, K Chalkidou, K Chalkidou, K Chalkidou, Karl Claxton, Laura Bojke, Louise Longworth, National Institute for Clinical Excellence, National Institute for Clinical Excellence, National Institute for Clinical Excellence, National Institute for Clinical Excellence, National Institute for Clinical Excellence, National Institute for Health and Clinical Excellence, National Institute for Health and Clinical Excellence, National Institute for Health and Clinical Excellence, National Institute for Health and Clinical Excellence, National Institute for Health and Clinical Excellence, National Institute for Health and Clinical Excellence, National Institute for Health and Clinical Excellence, National Institute for Health and Clinical Excellence, National Institute for Health and Clinical Excellence, National Institute for Health and Clinical Excellence, National Institute for Health and Clinical Excellence, National Institute for Health and Clinical Excellence, National Institute for Health and Clinical Excellence, National Institute for Health and Clinical Excellence Citizens Council, SR Tunis, Stephen Palmer, Susan Griffin, T Stafinski   +39 more
core   +2 more sources

Novel Therapeutics for Chronic Obstructive Pulmonary Disease: From Empirical Bronchodilation to Precision Medicine

Respirology, EarlyView.
ABSTRACT Chronic obstructive pulmonary disease (COPD) remains the third leading cause of death worldwide, and conventional bronchodilator‐based therapies have limited efficacy in preventing exacerbations and disease progression. The 2024–2026 period represents a historic inflection point: three mechanistically distinct agents received Food and Drug ...
Naoya Fujino, Hisatoshi Sugiura
wiley   +1 more source

Thai Translation and Validation of Chronic Rhinosinusitis‐Patient Reported Outcome (CRS‐PRO)

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objectives The Chronic Rhinosinusitis Patient‐Reported Outcome (CRS‐PRO) questionnaire was recently developed for use in chronic rhinosinusitis (CRS) patients. This instrument was developed using current diagnostic criteria. This study aimed to translate and validate CRS‐PRO for Thai CRS patients.
Wirach Chitsuthipakorn, Vorachai Pooldum, Juthaporn Phetpong, Saranath Lawpoolsri, Dichapong Kanjanawasee, Patlada Kowatanamongkon, Kittichai Mongkolkul, Kachorn Seresirikachorn, Kornkiat Snidvongs   +8 more
wiley   +1 more source