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Self-reported pharmacogenetic medication use in the Our Future Health cohort
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An updated review of pharmacokinetic drug interactions and pharmacogenetics of statins
Expert Opinion on Drug Metabolism & Toxicology, 2020Introduction Hydroxymethylglutaryl-coenzyme A reductase inhibitors (statins) lower cholesterol synthesis in patients with hypercholesterolemia. Increased statin exposure is an important risk factor for skeletal muscle toxicity.
Takeshi Hirota, Yuito Fujita, I. Ieiri
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The American Journal of Medicine, 1962
The term Pharmacogenetics is defined as the study of genetically determined variations in animal species which are revealed by the effects of drugs.I am going to deal with examples of these variations which have been found in Man. I must apologise for a certain amount of repetition of some facts which have already been aired in this conference, but it ...
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The term Pharmacogenetics is defined as the study of genetically determined variations in animal species which are revealed by the effects of drugs.I am going to deal with examples of these variations which have been found in Man. I must apologise for a certain amount of repetition of some facts which have already been aired in this conference, but it ...
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Primary Care: Clinics in Office Practice, 2004
This article provides an introduction to the discipline of pharmacogenetics and discusses the implications of pharmacogenetics research for primary care practice. Examples are given of how genetic information can predict and inform; drug interactions influencing drug efficacy, metabolism, dosing, and toxicity.
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This article provides an introduction to the discipline of pharmacogenetics and discusses the implications of pharmacogenetics research for primary care practice. Examples are given of how genetic information can predict and inform; drug interactions influencing drug efficacy, metabolism, dosing, and toxicity.
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Annual Review of Medicine, 2010
Warfarin is a drug with a narrow therapeutic index and a wide interindividual variability in dose requirement. Because it is difficult to predict an accurate dose for an individual, patients starting the drug are at risk of thromboembolism or bleeding associated with underdosing or overdosing, respectively.
Kamali F, Wynne H
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Warfarin is a drug with a narrow therapeutic index and a wide interindividual variability in dose requirement. Because it is difficult to predict an accurate dose for an individual, patients starting the drug are at risk of thromboembolism or bleeding associated with underdosing or overdosing, respectively.
Kamali F, Wynne H
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Veterinary Clinics of North America: Small Animal Practice, 2006
Pharmacogenetics, the study of genetic determinants of response to drug therapy, is likely the ultimate way to establish the right drug and dose for each patient, thereby optimizing efficacy and minimizing toxicity. Despite the fact that this branch of pharmacology is still in its infancy as a science, a number of important discoveries have already ...
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Pharmacogenetics, the study of genetic determinants of response to drug therapy, is likely the ultimate way to establish the right drug and dose for each patient, thereby optimizing efficacy and minimizing toxicity. Despite the fact that this branch of pharmacology is still in its infancy as a science, a number of important discoveries have already ...
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The pharmacogenetics of analgesia
Expert Opinion on Pharmacotherapy, 2007Genomic variations influencing response to pharmacotherapy of pain are under investigation. Candidate genes such as (opioid)-receptors, transporters and other molecules important for pharmacotherapy are discussed. Drug metabolising enzymes represent a further major target of ongoing research in order to identify associations between an individual's ...
Frank Stüber, Ulrike M. Stamer
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