Results 41 to 50 of about 477,265 (189)

Targeting HSP90 sensitizes pancreas carcinoma to PD-1 blockade

OncoImmunology, 2022
Interferon gamma (IFNG/IFNγ)-induced adaptive immune resistance remains a challenge for tumor therapy. We observed that the chaperone heat shock protein 90 (HSP90) stabilizes the transcription factor signal transducer and activator of transcription 1 ...
Jiao Liu, Rui Kang, Guido Kroemer, Daolin Tang   +3 more
doaj   +1 more source

Behavioral defects in chaperone-deficient Alzheimer's disease model mice. [PDF]

, 2011
Molecular chaperones protect cells from the deleterious effects of protein misfolding and aggregation. Neurotoxicity of amyloid-beta (Aβ) aggregates and their deposition in senile plaques are hallmarks of Alzheimer's disease (AD).
Alvin V Terry, Alvin V. Terry, Rajalakshmi V Karmegam, Rajalakshmi V. Karmegam, J. Gunasingh Masilamoni, Juhi Ojha, Masilamoni J. Gunasingh, Anil G Cashikar, Anil G. Cashikar, Cashikar Anil G., Terry Alvin V., Karmegam Rajalakshmi V., J Gunasingh Masilamoni, Ojha Juhi, Terry, Alvin, Ojha, Juhi, Karmegam, Rajalakshmi, Masilamoni, J. Gunasingh, Cashikar, Anil   +18 more
core   +1 more source

Pharmacological chaperones in the age of proteomic pathology [PDF]

Proceedings of the National Academy of Sciences, 2014
In the age of “big data,” where thousands of proteins or protein precursors can be interrogated and assembled into large-scale networks, it is still the case that in the setting of disease singular proteins act as hubs in driving pathology (1). Once identified, a pathogenic protein—which can be deficient, dysfunctional, or even overly abundant—becomes ...
openaire   +2 more sources

Crystal structure of the Yersinia enterocolitica type III secretion chaperone SycD in complex with a peptide of the minor translocator YopD [PDF]

, 2012
Schreiner M, Niemann H. Crystal structure of the Yersinia enterocolitica type III secretion chaperone SycD in complex with a peptide of the minor translocator YopD. BMC Structural Biology. 2012;12(1): 13.Background Type III secretion systems are used by
Niemann, H.H., Madeleine Schreiner, Hartmut H Niemann, Schreiner, Madeleine, Schreiner, M., Niemann, Hartmut ; https://orcid.org/   +5 more
core   +1 more source

What are pharmacological chaperones and why are they interesting? [PDF]

Journal of Biology, 2009
We should have said, reversible inhibitor. That is the key to the use of active-site-directed ligands as pharmacological chaperones. An inhibitor that binds irreversibly to a target protein takes that protein out of circulation, activity-wise. But a reversible inhibitor always allows the presence of some equilibrium amount of free enzyme [12], which is
Ringe, Dagmar, Petsko, Gregory A
openaire   +2 more sources

Pharmacological rescue of trafficking-impaired ATP-sensitive potassium channels

Frontiers in Physiology, 2013
ATP-sensitive potassium (KATP) channels link cell metabolism to membrane excitability and are involved in a wide range of physiological processes including hormone secretion, control of vascular tone, and protection of cardiac and neuronal cells against ...
Gregory M. Martin, Pei-Chun eChen, Prasanna eDevaraneni, Show-Ling eShyng   +3 more
doaj   +1 more source

Targeted stabilization of Munc18‐1 function via pharmacological chaperones

EMBO Molecular Medicine, 2020
Heterozygous de novo mutations in the neuronal protein Munc18‐1 cause syndromic neurological symptoms, including severe epilepsy, intellectual disability, developmental delay, ataxia, and tremor.
Debra Abramov, Noah Guy Lewis Guiberson, Andrew Daab, Yoonmi Na, Gregory A Petsko, Manu Sharma, Jacqueline Burré   +6 more
doaj   +1 more source

Targeting retinoic acid receptor alpha-corepressor interaction activates chaperone-mediated autophagy and protects against retinal degeneration

, 2022
Chaperone-mediated autophagy activity, essential in the cellular defense against proteotoxicity, declines with age, and preventing this decline in experimental genetic models has proven beneficial.
Xin, Qisheng, McCabe, Mericka, Diaz, Antonio, Gavathiotis, Evripidis, Fernando Macian, Ana Maria Cuervo, Gomez-Sintes, Raquel, Pedro de la Villa, Mericka McCabe, Shuxian Dong, Wu, Yang, Yang Wu, de la Villa, Pedro, Garner, Thomas P., Raquel Gomez-Sintes, Evripidis Gavathiotis, Antonio Diaz, Boya, Patricia, Xiomaris M. Cotto-Rios, Cara A. Reynolds, Bindi Patel, Patricia Boya, Reynolds, Cara A., Thomas P. Garner, Juan Ignacio Jimenez-Loygorri, Jimenez-Loygorri, Juan Ignacio, Dong, Shuxian, Qisheng Xin, Cotto-Rios, Xiomaris M., Patel, Bindi, Macian, Fernando, Cuervo, Ana Maria   +31 more
core   +1 more source

Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease. [PDF]

PLoS Biology, 2010
Neurodegenerative diseases such as Huntington disease are devastating disorders with no therapeutic approaches to ameliorate the underlying protein misfolding defect inherent to poly-glutamine (polyQ) proteins.
Daniel W Neef, Michelle L Turski, Dennis J Thiele   +2 more
doaj   +1 more source

Therapeutic Role of Pharmacological Chaperones in Lysosomal Storage Disorders: A Review of the Evidence and Informed Approach to Reclassification

Biomolecules, 2023
The treatment landscape for lysosomal storage disorders (LSDs) is rapidly evolving. An increase in the number of preclinical and clinical studies in the last decade has demonstrated that pharmacological chaperones are a feasible alternative to enzyme ...
Ian Keyzor, Simon Shohet, Jeff Castelli, Sheela Sitaraman, Biliana Veleva-Rotse, Jill M. Weimer, Brian Fox, Tobias Willer, Steve Tuske, Louise Crathorne, Klara J. Belzar   +10 more
doaj   +1 more source