Results 111 to 120 of about 25,555 (231)

Catalytic Asymmetric Synthesis of gem‐Dicyano‐Spirocyclopropyl Oxindoles by N‐9‐Anth‐PyBidine‐Co(OAc)2: Advantage of Three‐Component Coupling Approach

ChemistryEurope, Volume 4, Issue 3, March 2026.
Chiral gem‐dicyano‐spirocyclopropyl oxindoles are obtained by a chiral N‐9‐Anth‐PyBidine‐Co(OAc)2‐catalyzed asymmetric Michael/alkylation reaction of 3‐chlorooxindoles with alkylidenemalononitriles. The three‐component coupling reaction of 3‐chlorooxindoles, aldehydes, and malononitrile shows the advantage of not requiring the preparation of ...
Takaaki Saito, Ren Miyasaka, Kazumasa Kon, Yuri Takagi, Takayoshi Arai   +4 more
wiley   +1 more source

Gold–Thiopurine and Thioguanine Platforms for Chemotherapy and Photodynamic Therapy

ChemistryEurope, Volume 4, Issue 3, March 2026.
Gold(I)–thiopurine complexes bearing chromophores and phosphine or N‐heterocyclic carbene ligands were developed as multimodal chemo‐photodynamic agents. They show good stability, moderate lipophilicity, and tunable photoresponse. 6‐TG enhances dark cytotoxicity, 6‐MP improves phototoxicity, and PPh3/NBD provide the most efficient photoactivation ...
Laura Agulló, Juan Carlos Pérez‐Sánchez, María Gil‐Moles, M. Concepción Gimeno   +3 more
wiley   +1 more source

Ligand-Based Pharmacophore Mapping and Virtual Screening for the Search of Biguanide-Like Molecules With Antidiabetic Potentials Targeting Liver Kinase B1. [PDF]

Biochem Res Int
Reza R, Samdani MN, Morshed N, Jebin RH, Ahmed I, Reza MS.   +5 more
europepmc   +1 more source

Photoisomerization in Cyclic Dipeptide Derivatives: Photoswitchable Supramolecular Hydrogels and the Discovery of Hemipiperazine Photoswitches

ChemPhotoChem, Volume 10, Issue 3, March 2026.
Photoswitchable cyclic dipeptides (CDPs) can be used to prepare hydrogels that reversibly dissipate upon irradiation, or to photomodulate the development of living organisms. We report here applications and perspectives for CDPs containing azobenzene photoswitches or newly discovered hemipiperazine photoswitches in smart materials and biological ...
Zbigniew L. Pianowski
wiley   +1 more source

Blocking ASIP to Protect MC1R Signaling and Mitigate Melanoma Risk: An In Silico Study. [PDF]

Pharmaceuticals (Basel)
Maarfi F, Cherkaoui M, Afreen S, Khan MY.   +3 more
europepmc   +1 more source

A Freshwater Pearl Mussel Polysaccharide Alleviates Inflammatory Pain by Targeting Peripheral Cytokines and Spinal Astroglial NLRP3/GFAP Responses

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
Mussel polysaccharide (MP), a novel food resource from pearl mussels, alleviates inflammatory pain in rats in a dose‐dependent manner. It acts by dually inhibiting peripheral inflammation (reducing paw swelling and pro‐inflammatory cytokines) and spinal neuroinflammation via the NLRP3 and astrocyte pathway.
Chen Hu, Weiwei Xu, Yingjian Zhu, Yushan He, Jiayuan Xu, Xiaomei Wang, Furong Niu, Guangming Chen, Hongchang Zhou   +8 more
wiley   +1 more source

Virtual screening of compounds for the development of thyroid hormone analogues for potential application in cardiac regeneration. [PDF]

J Comput Aided Mol Des
de Oliveira Filho JA, Chaves EJF, Pascutti PG, de Morais Gomes ER.   +3 more
europepmc   +1 more source

Therapeutic Efficacy and Safety Profile of Eplontersen in Hereditary Transthyretin‐Mediated Amyloidosis: A Systematic Review

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Hereditary transthyretin‐mediated amyloidosis (hATTR) is a disorder that affects several body systems and can result in life‐threatening conditions like cardiomyopathy and polyneuropathy. For treatment of hATTR in the new medical realm, there is a breakthrough discovery of a medicine called Eplontersen, which targets the underlying ...
Zeel Vishnubhai Patel, Verkha Kumari, Paras, Bethineedi Lakshmi Deepak, Priyadarshi Prajjwal, Kolanu Nikhil Deep, Rakhi Bai, Serene Sara John, Omniat Amir Hussin   +8 more
wiley   +1 more source

CMCL-DDI: Pharmacophore-aware cross-view contrastive learning for drug-drug interaction prediction. [PDF]

PLoS One
Han Y, Du L.
europepmc   +1 more source

Artificial intelligence strategies for predicting kinase inhibitor resistance: A comprehensive review of methods, challenges, and future perspectives

Journal of Intelligent Medicine, Volume 3, Issue 1, Page 26-46, March 2026.
Abstract Kinase inhibitors are essential in targeted cancer therapy, yet resistance often emerges through secondary mutations, activation of compensatory signaling pathways, or drug‐efflux mechanisms. Artificial intelligence (AI) provides a workflow‐based strategy rather than a list of unrelated tools for predicting and addressing kinase‐inhibitor ...
Faris Hassan, Mohanad Ali Deifallah, Alaa Zaghloul, Rania Elgohary   +3 more
wiley   +1 more source