Results 21 to 30 of about 35,678 (209)

Regulation of Radiopharmaceutical Products

Регуляторные исследования и экспертиза лекарственных средств, 2022
The fast development of diagnostic and therapeutic radionuclide technologies requires enhanced legislative regulation of radiopharmaceuticals. The article addresses the challenge of classifying radiopharmaceuticals depending on the manufacturing ...
V. V. Kosenko, A. A. Trapkova, S. N. Kalmykov   +2 more
doaj   +1 more source

Modern methods for identification and quantification of cardiac glycosides

Регуляторные исследования и экспертиза лекарственных средств, 2023
Scientific relevance. Cardiac glycosides have been used in medicine for over two centuries. Current studies suggest that biologically active substances from this group can be used to treat not only heart conditions but also viral infections, cancers, and
O. V. Evdokimova, A. V. Beketova, O. A. Naumova, I. V. Klinkova, T. B. Shemeryankina, L. A. Ladygina, K. S. Bushchik   +6 more
doaj   +1 more source

Preliminary studies of acute and sub-chronic toxicity of the aqueous extract of Guibourtia tessmannii (Harms) J. Leonard stem barks (Caesalpiniaceae) in mice and rats

Asian Pacific Journal of Tropical Biomedicine, 2016
Objective: To investigate the toxicity of aqueous extract of Guibourtia tessmannii (Harms) J. Leonard (G. tessmannii) and evaluate its safety. Methods: NMRI mice were used to determine the acute toxicity of G. tessmannii. Increasing concentrations of the
Noreen Orianna Koumba Madingou, Aristide Traore, Alain Souza, Marlaine Michelle Boukandou Mounanga, Raissa Reine Aworet Samseny, Sylvin Ouedraogo, Alfred Sababenedyo Traore   +6 more
doaj   +1 more source

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

Impacts of SAYE PLUS, an Antimalarial Phytomedicine With Potential Anti-COVID-19, on the Physical, Biological, and Genotoxicity Parameters of Rodents in Short-Term Toxicity Studies

Journal of Toxicology
In response to the COVID-19 pandemic and following the World Health Organization’s call for action, several traditional medicine recipes were used without any scientific prerequisites concerning their safety.
Joël Ouédraogo, Sylvain Ilboudo, Geoffroy Gueswindé Ouédraogo, Virginie Dakuyo, Salfo Ouédraogo, Gaétan D. Somda, Jean Claude Romaric Pingdwindé Ouédraogo, Moussa Ouédraogo, Rasmané Semdé, Sylvin Ouédraogo   +9 more
doaj   +1 more source

Innovative Test Strip‐Based Colorimetric Sensors Integrated With Affinity Chromatography: Acetylcholinesterase Inhibitor Screening Breakthrough in Lycium Barbarum Leaves

Advanced Science, EarlyView.
Schematic diagrams illustrating the breakthrough in the screening of AChE inhibitors from LBL, and the research process of the pharmacodynamics of the NCP are presented. ABSTRACT Current Alzheimer's drugs exhibit limited effectiveness, highlighting the necessity for multi‐target treatments.
Yuping Sa, Hui Yuan, Jingui Ma, Zhigang Yang, Mei Wang, Weibiao Wang, Lingling Yang, Fen Ma, Weiman Zhang, Gidion Wilson Mening'oo, Guoning Chen, Xueqin Ma   +11 more
wiley   +1 more source

Uhrf1‐Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease

Advanced Science, EarlyView.
Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang, Xin‐Rong Xu, Hui‐Lin Zhang, Qi‐Meng Zhu, Xin‐Yuan Li, Xi‐Peng Shang, Jing‐Hui Du, Christophe Morisseau, Feng Qiu, Cheng‐Peng Sun   +9 more
wiley   +1 more source

Eudragit®‐engineered pH‐responsive probiotic microspheres with enhanced gastrointestinal resistance and prolonged storage stability for inflammatory bowel disease therapy

BMEMat, EarlyView.
This study reports the development of AMS@Eud core‐shell microspheres, combining calcium alginate and pH‐responsive Eudragit® L100, which exhibit exceptional gastrointestinal resistance and long‐term storage stability (only 5.28%–9.09% viability loss over 35 days at 4–25°C), and effectively alleviate inflammatory bowel disease via gut microbiota ...
Ming Teng, Xiaomin Luo, Peng Zhang, Chen Yang, Yuniel Ma, Xinhua Liu   +5 more
wiley   +1 more source

Xylose Acetals ‐ a New Class of Sustainable Solvents and Their Application in Enzymatic Polycondensation

ChemSusChem, Volume 18, Issue 6, March 15, 2025.
Novel organic solvents with an unmodified carbohydrate core were synthesised both from D‐xylose and directly from biomass and were successfully used as reaction media for lipase biocatalysts to synthesise aliphatic and aromatic polyesters. Abstract The use of organic solvents in academic research and industry applications is facing increasing ...
Anastasia O. Komarova, Cicely M. Warne, Hugo Pétremand, Laura König‐Mattern, Johannes Stöckelmaier, Chris Oostenbrink, Georg M. Guebitz, Jeremy Luterbacher, Alessandro Pellis   +8 more
wiley   +1 more source

Efforts to Prevent the Neglect of Traditional Indigenous Medicine: Policy Insights From Bolivia

The International Journal of Health Planning and Management, EarlyView.
ABSTRACT Traditional Indigenous medicine has existed for centuries, but only recently has it obtained international recognition. Some countries have been working on the integration of traditional Indigenous healing practices in their national health systems.
Carlos Rosas‐Jiménez, Roberto Tola, Melina Flores, Sonia Cruz, Gonzalo Huanca, Cynthia Lokker, Bonny Ibhawoh, Lisa Schwartz   +7 more
wiley   +1 more source