Results 51 to 60 of about 4,080 (160)

Rethinking the AI Paradigm for Solubility Prediction of Drug‑Like Compounds with Dual‐Perspective Modeling and Experimental Validation

Advanced Science, Volume 12, Issue 46, December 11, 2025.
Aqueous solubility governs drug delivery and bioavailability, yet its prediction remains challenging. Utilizing the largest curated dataset of drug‐like molecules, prediction models are constructed through dual‐perspective benchmarking. Stacking methods outperform advanced deep learning due to data constraints. These validated models enabled systematic
Qilin Zhu, Yuxin Qiu, Guzhong Chen, Wenyao Chen, Xiang Zhang, Zhiwen Qi, Xuezhi Duan, De Chen, Zhen Song   +8 more
wiley   +1 more source

Modern methods for identification and quantification of cardiac glycosides

Регуляторные исследования и экспертиза лекарственных средств, 2023
Scientific relevance. Cardiac glycosides have been used in medicine for over two centuries. Current studies suggest that biologically active substances from this group can be used to treat not only heart conditions but also viral infections, cancers, and
O. V. Evdokimova, A. V. Beketova, O. A. Naumova, I. V. Klinkova, T. B. Shemeryankina, L. A. Ladygina, K. S. Bushchik   +6 more
doaj   +1 more source

A Novel Semi‐Automated Pipeline for Optimizing 3D‐Printed Drug Formulations

Advanced Intelligent Systems, Volume 7, Issue 11, November 2025.
A novel, semi‐automated deep learning and differential evolution pipeline designed for generating medicines for 3D‐printed medicines is introduced. This pipeline successfully generates a diverse range of drug formulations with an 80% printing success rate and 92% accuracy in predicting printing parameters.
Youssef Abdalla, Martin Ferianc, Haya Alfassam, Atheer Awad, Ruochen Qiao, Miguel Rodrigues, Mine Orlu, Abdul W. Basit, David Shorthouse   +8 more
wiley   +1 more source

Evaluation of the binder effect of Pentadesma butyracea gum on the mechanical characteristics of paracetamol tablets

Scientific African
Natural gums are widely studied as safe, affordable, and accessible pharmaceutical excipients, yet many indigenous gums remain poorly characterized, highlighting the need for locally viable binder alternatives.
Mary-Ann Archer, Kwabena Ofori-Kwakye, Raphael Johnson, Isaac Yaw Attah, Samuel Lugrie Kipo, Mariam El Boakye-Gyasi, Frederick William Akuffo Owusu, Emmanuel Awintiig Adakudugu, Doris Kumadoh   +8 more
doaj   +1 more source

Quantification of three macrolide antibiotics in pharmaceutical lots by HPLC: Development, validation and application to a simultaneous separation [PDF]

, 2016
A new validated high performance liquid chromatographic (HPLC) method with rapid analysis time and high efficiency, for the analysis of erythromycin, azithromycin and spiramycin, under isocratic conditions with ODB RP18 as a stationary phase is described.
Bahrami, G., Mirzae, S., Kiani, A., Cachet, Th., Kibwage, I.O., Roets, E., Hoogmartens, J., Vanderhaeghe, H., Cao, Z., Liu, B., Liu, W., Su, Y., Bo, W., Yao, G., Chepkwony, H.K., Dehouck, P., Roets, E., Hoogmartens, J., Chepkwony, H.K., Dehouck, P., Roets, E., Hoogmartens, J., Chepkwony, H.K., Roets, E., Hoogmartens, J., Chepkwony, H.K., Vanderriest, I., Nguyo, J.M., Roets, E., Hoogmartens, J., Chepkwony, H.K., Vermaelen, A., Roets, E., Hoogmartens, J., Dolan, J.W., Dubois, M., Fluchard D., Sior E., Delahaut Ph., Duthu, G.S., Edder, P., Coppex, L., Cominoli, A., Corvi, C., Furusawa, N., Gonzalez de la Huebra, M.J., Vincent, U., Bordin, G., Rodriguez, A.R., Gonzalez de la Huebra, M.J., Vincent, U., Holst, C., Kanfer, I., Skinner, M.F., Walker, R.B., Kauss, T., Gaudin, K., Gaubert, A., Ba, B., Tagliaferri, S., Fawaz, F., Fabre, J-L., Boiron, J-M., Lafarge, X., White, NJ., Olliaro, PL., Millet, P., Khashaba, P.Y., KLalloo, A., Kanfer, I., Lahane, S.B., Deokate, U.A., Ahire, S., Mahmoudi, A., Fourar, R.E.-A., Boukhechem, M.S., Zarkout, S., Shen, Y., Yin, C., Su, M., Tu, J., Yang, Z.Y., Wang, L., Tang, X.   +22 more
core   +1 more source

Analytical Method by Headspace‐Gas Chromatography for Determination of Six Residual Solvents in Losartan Potassium Raw Material

Journal of Separation Science, Volume 48, Issue 11, November 2025.
ABSTRACT Residual solvents, or organic volatile impurities, are a potential toxic risk for pharmaceutical products and have been a manufacturers’ concern for many years. Moreover, residual solvents can also affect the quality and stability of not only drug substances but also of drug products.
Vanessa B. de Camargo, Cássia V. Garcia
wiley   +1 more source

Dual antibiotherapy of tuberculosis mediated by inhalable locust bean gum microparticles [PDF]

, 2017
Despite the existence of effective oral therapy, tuberculosis remains a deadly pathology, namely because of bacterial resistance and incompliance with treatments.
Alves, Ana D., Buttini, Francesca, Cavaco, Joana S., Grenha, Ana, Guerreiro, Filipa, Pontes, Jorge Filipe, Rodrigues, Susana, Rosa Da Costa, Ana   +7 more
core   +1 more source

Model‐informed exploration of the boundaries of safe aluminium exposure from allergen immunotherapy in children

Pediatric Allergy and Immunology, Volume 36, Issue 8, August 2025.
Abstract Background The safety of aluminium (Al) exposure from medicinal products for subcutaneous allergen immunotherapy (SCIT) is still under debate due to their administration in many doses over years. Especially for children, model‐informed risk assessment is urgently needed in the absence of clinical study data.
Karin Weisser, Gaby Wangorsch, Niklas Hartung, Wilhelm Huisinga, Brigitte Keller‐Stanislawski   +4 more
wiley   +1 more source

Combining Selective Laser Sintering and Fused Deposition Modeling of Pharmaceutical Polymers: A Novel Approach to Prepare Intestine‐Targeted Tablets

Macromolecular Materials and Engineering, Volume 310, Issue 6, June 2025.
Selective laser sintering (SLS) and fused deposition modeling (FDM) are combined to prepare intestine‐targeted tablets with controlled drug release. The SLS‐printed core contains a model drug. The FDM‐printed coating shell modifies drug release and increases tablet mechanical resistance.
Thao Tranová, Kevin Matzick, Jan Loskot, Jana Macháčková, Marie Nevyhoštěná, Oliver Macho, Vladimíra Trnčáková, Alena Komersová, Jitka Mužíková   +8 more
wiley   +1 more source

THE ROLE OF REFERENCE STANDARDS IN QUALITY ASSURANCE FOR MEDICINES: REGULATORY AND METROLOGICAL ASPECTS

Разработка и регистрация лекарственных средств, 2019
Some aspects of the adequate use of reference standards (RS) for making a reliable decision on the compliance of medicines are reviewed. An analysis of the specificity of using RS with the certified value and substance/reagent, for which the nominal ...
D. A. Leontiev, Y. V. Podpruzhnikov, N. V. Volovyk   +2 more
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