Results 111 to 120 of about 62,672 (281)

Estimated Incidence of Hospitalizations and Deaths Attributable to Respiratory Syncytial Virus Infections Among Adults in Germany Between 2015 and 2019

Infectious Diseases and Therapy
Introduction Respiratory syncytial virus (RSV) burden in adults is underestimated mainly due to unspecific symptoms and limited standard-of-care testing.
Aleksandra Polkowska-Kramek, Elizabeth Begier, Robin Bruyndonckx, Caihua Liang, Caroline Beese, Gordon Brestrich, Thao Mai Phuong Tran, Charles Nuttens, Maribel Casas, Lea Johanna Bayer, Bennet Huebbe, Worku Biyadgie Ewnetu, Juan Luis Ramirez Agudelo, Bradford D. Gessner, Christof von Eiff, Gernot Rohde   +15 more
doaj   +1 more source

A systematic review and pharmacovigilance analysis of the risk of agranulocytosis associated with metamizole use

Scientific Reports
Metamizole is an analgesic widely used after its introduction but later withdrawn in several countries due to the risk of agranulocytosis. Despite this, it remains frequently used worldwide.
Alessia Zinzi, Mario Gaio, Donatella Ruggiero, Consiglia Riccardi, Cecilia Cagnotta, Ciro Pentella, Annalisa Capuano, Concetta Rafaniello   +7 more
doaj   +1 more source

Evaluating the Evolving Real‐World Adverse Events of GLP‐1RAs Using FDA Adverse Event Reporting System (FAERS)

Obesity, EarlyView.
Web portal for interrogating Adverse Events of GLP‐1 RA in diabetes vs weight control/obesity. ABSTRACT Objective This study aimed to assess the spectrum and frequency of adverse events (AEs) linked to glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) using the US FDA Adverse Event Reporting System (FAERS).
David Stone, Mary Playdon, Stephen D. Hursting, Aik Choon Tan   +3 more
wiley   +1 more source

Traditional Chinese Medicine for lung cancer: Mechanisms, clinical evidence, and future perspectives

Precision Medical Sciences, EarlyView.
Graphical abstract represents the risk factors for lung cancer, TCM efficacy and clinical outcomes to future challenges. Abstract Lung cancer remains a leading cause of global cancer mortality. Despite advances in conventional treatments such as surgery, chemotherapy, targeted therapy, and immunotherapy, challenges including drug resistance, toxicity ...
Zhangdeng Chen, Liujun Bao
wiley   +1 more source

Safety of 12‐Months Administration of Ashwagandha (Withania somnifera) Standardized Root Extract in Healthy Adults: A Prospective, Observational Study

Phytotherapy Research, EarlyView.
ABSTRACT Ashwagandha, an adaptogen, is an important herb of Ayurveda used as a Rasayana for its various health benefits. This prospective, multi‐center, observational clinical study evaluates the safety (clinical and laboratory) of a standardized Ashwagandha Root Extract (ARE) on long‐term administration over 12 months. Male and female adults (N = 191)
Jaising Salve, Sanjeev Kale, Banwari Lal Prajapati, Adele Sparavigna, Mark Savant, John Ademola, Deepak Langade   +6 more
wiley   +1 more source

Ashwagandha: Is It Safe? Part 1: A Regulatory Review

Phytotherapy Research, EarlyView.
ABSTRACT Over the last decade, ashwagandha (Withania somnifera (L.) Dunal, AS) has been brought under increasing scrutiny by EU regulators regarding its safety for the use in food supplements, culminating in a recent recommendation for an Article 8 procedure according to Regulation (EC) No. 1925/2006 in the European Union (EU).
T. Brendler, R. Al‐Mondhiry, L. Lang, R. Marles, M. Tallon, A. Raghu   +5 more
wiley   +1 more source

Medical Literature in the Age of Artificial Intelligence

iNew Medicine, EarlyView.
Hunter Scott
wiley   +1 more source

Trends and Patterns for the Use of Herbal Medicinal Products for Gynaecological Ailments

Phytotherapy Research, EarlyView.
ABSTRACT Most Germans consider herbal medicinal products (HMPs) to be an important supplement to conventional medicine. Despite existing clinical evidence for safety and efficacy, they are still not sufficiently integrated into drug therapy of gynaecological complaints in everyday practice.
Alexandra Drebka, Annika J. Scholl, Teresa Ochs, Olaf Kelber, Ralph Mösges, Beatrice E. Bachmeier   +5 more
wiley   +1 more source

Big data in veterinary medicines regulation: A data landscape analysis to support regulatory activities

Veterinary Record, EarlyView.
Abstract Background This study describes the development of a data landscape analysis protocol that identifies and characterises animal health data sources to support key regulatory activities throughout the life cycle of veterinary medicines. Methods The protocol included: development of criteria to identify data sources; selection of variables to ...
Ewa Pacholewicz, Eduardo de Freitas Costa, Mariana Avelino de Souza Santos, Bjorn Berendsen, Jos A. A. M. Verstegen   +4 more
wiley   +1 more source

Type I and II Interferons Drive Abacavir Hypersensitivity via Treg Suppression and T‐Cell Enhancement in Immunocompetent HLA‐Transgenic Mice

Allergy, EarlyView.
Upregulated HLA‐B*57:01 expression in Tg/KO mice amplifies abacavir‐specific CD8+ T‐cell activation, driven by enhanced antigen presentation. Abacavir treatment induces robust pDC expansion and IFN‐α production, which selectively suppresses memory Treg populations.
SuJin Hwang, Telly Sepahpour, Stephanie Kortchak, Kirthiram Krishnaveni Sivakumar, Spyros Karaiskos, Ngoc Pham, Yura Jang, Montserrat Puig, Michael Norcross   +8 more
wiley   +1 more source