Results 241 to 250 of about 51,036 (300)

Evaluating Large‐Language Models in Bioinformatics Applications

Advanced Computing, Volume 1, Issue 1, December 2026.
This work systematically evaluates advanced large language models across six representative bioinformatics tasks, from drug–drug interaction prediction and molecular optimization to single‐cell annotation and computational biology problem solving. The benchmark quantifies both their promise and limitations, offering practical guidance for prompt design,
Hengchuang Yin, Ziwen Cui, Dongxu Li, Yue Yang, Ying Chang, Xiaobo Zhu, Jun Zhang, Pengwei Hu, Xi Zhou, Lun Hu   +9 more
wiley   +1 more source

Potential association of cluster headache with certain COVID-19 vaccines: An assessment from the pharmacovigilance databases. [PDF]

Headache
Van Obberghen EK, Parigny L, Ben-Othman N, Ewig E, Drici MD, Gérard AO, Gautier S, Lanteri-Minet M.   +7 more
europepmc   +1 more source

The Kush Drug Epidemic in Sierra Leone: Public Health Implications, Socioeconomic Drivers and Health System Responses

Public Health Challenges, Volume 5, Issue 4, December 2026.
ABSTRACT Background Kush, a synthetic drug combining cannabinoids and nitazene opioids, has emerged as a major public health concern in Sierra Leone, with reported prevalence and clinical severity increasing markedly as it was first identified.
Alvin Turay, Ahmed Vandy, Uthman Okikiola Adebayo, Marie Ibranatu Kolipha‐Kamara, Augustus Osborne, Michael Lahai   +5 more
wiley   +1 more source

Correction to 'Adverse Event Profile of Apremilast: Pharmacovigilance Study Based on FDA Adverse Event Reporting System (FAERS)'. [PDF]

Exp Dermatol
europepmc   +1 more source

Safety profile of entrectinib in NSCLC: Multi-source pharmacovigilance analysis using FAERS and JADER. [PDF]

PLoS One
Yang J, Liu J, Zhao G, Li H, Sun G.
europepmc   +1 more source

Cardiovascular and neuropsychiatric outcomes with PCSK9 inhibitors in atherosclerotic cardiovascular disease: A retrospective cohort study

British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3862-3873, November 2026.
Study design and main findings. After 1:1 propensity score matching, 60 885 PCSK9 inhibitor users and 60 885 statin‐only users with ASCVD were compared. Kaplan–Meier curves show 12‐month cumulative event‐free survival for MACE, psychiatric disease, and neurodegenerative disease.
Tianshu Gu, Yang Chen, Nan Zhang, Uazman Alam, Riccardo Proietti, Tong Liu, Kang‐Yin Chen, Gregory Y. H. Lip   +7 more
wiley   +1 more source

Pharmacovigilance [PDF]

, 2002
openaire   +1 more source

Impact of the pancreatic enzyme replacement therapy (PERT) shortage on prescribing in England: Analysis of national data

British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3926-3938, November 2026.
Aim Pancreatic enzyme replacement therapy (PERT) is essential for the management of pancreatic exocrine insufficiency. Since June 2023, the United Kingdom has been affected by a global shortage of PERT. We investigated the impact of this shortage on national prescribing trends for Creon, Nutrizym, Pancrex and Pangrol.
Teena S. Varghese, Mary E. Phillips, Louis Fisher, Helen Fitt, Adam Frampton, Christopher Wood, Agnieszka Lemanska   +6 more
wiley   +1 more source

Mechanism-aware and safety-validated AI for drug repurposing: a critical review and translational pharmacology framework. [PDF]

Front Pharmacol
Hazra M, Anandaram H.
europepmc   +1 more source

Capacity building in medicines development and regulation in Africa—Overview on recent progress

British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3759-3769, November 2026.
Aims Despite advances in health research and digital innovation, many African countries continue to face substantial resource constraints, fragmented capacity‐building efforts and a shortage of skilled professionals in medicines development and regulatory science.
Tirhani Maluleke, Emile Malan, Michael Reid, Patrick Bouic, Haylene Nell, Goonaseelan Pillai, Catriona Waitt, Bernd Rosenkranz   +7 more
wiley   +1 more source