Results 41 to 50 of about 62,672 (281)

A Model-Based Estimation of RSV-Attributable Incidence of Hospitalizations and Deaths in Italy Between 2015 and 2019

Infectious Diseases and Therapy
Introduction Respiratory syncytial virus (RSV) incidence is known to be underestimated in adults due to its infrequent diagnostic testing and lower sensitivity of single nasal/nasopharyngeal swab PCR testing outside of the early childhood period. RSV can
Estelle Méroc, Caihua Liang, Raffaella Iantomasi, Chukwuemeka Onwuchekwa, Giuseppe Pietro Innocenti, Daniela d’Angela, Solomon Molalign, Thao Mai Phuong Tran, Somsuvro Basu, Bradford D. Gessner, Robin Bruyndonckx, Aleksandra Polkowska-Kramek, Elizabeth Begier   +12 more
doaj   +1 more source

Pharmacovigilance of suspected or confirmed therapeutic ineffectiveness of artemisinin-based combination therapy: extent, associated factors, challenges and solutions to reporting

Malaria Journal, 2020
Background Therapeutic ineffectiveness of artemisinin-based combination therapy (ACT) increases the risk of malaria-related morbidity and mortality, and raises healthcare costs.
Ronald Kiguba, Helen Byomire Ndagije, Victoria Nambasa, Leonard Manirakiza, Elijah Kirabira, Allan Serwanga, Sten Olsson, Niko Speybroeck, Jackson Mukonzo   +8 more
doaj   +1 more source

SARS-CoV-2 Treatment: Current Therapeutic Options and the Pursuit of Tailored Therapy

Applied Sciences, 2021
One year on from the worldwide outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), medicine has made several steps towards increasing the therapeutic options against its treatment.
Gianmarco Marcianò, Roberta Roberti, Caterina Palleria, Davida Mirra, Vincenzo Rania, Alessandro Casarella, Giovambattista De Sarro, Luca Gallelli   +7 more
doaj   +1 more source

Sarilumab in Polyarticular‐Course Juvenile Idiopathic Arthritis: Dose‐Finding and 1‐Year Analysis of a Phase 2b, Open‐Label, Multicenter Study

Arthritis Care &Research, EarlyView.
Objective This study assessed sarilumab in treating patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods This phase 2b, open‐label study (NCT02776735) consisted of three sequential parts (each with a core‐treatment and extension phase).
Fabrizio De Benedetti, Inmaculada C. Penadés, Irina Nikishina, Ivan Foeldvari, Alberto J. Spindler, Anna Kozlova, Nadina Rubio‐Pérez, Pierre Quartier, Zbigniew Żuber, Raul Barria, Daniel Clemente, Gabriel V. Cornejo, Katherine Marzan, Nancy Liu, Christine Xu, Stephen DiMartino, Angeliki Giannelou, Fei Cao‐Ghoul, Bolanle Akinlade, Lydie Baret‐Cormel   +19 more
wiley   +1 more source

Estimated Incidence of Hospitalizations Attributable to RSV Infection Among Adults in Ontario, Canada, Between 2013 and 2019

Infectious Diseases and Therapy
Introduction Adult respiratory syncytial virus (RSV) burden is underestimated due to non-specific symptoms, limited standard-of-care and delayed testing, reduced diagnostic test sensitivity—particularly when using single diagnostic specimen—when compared
Marianna Mitratza, Malak Elsobky, Caihua Liang, Robin Bruyndonckx, Aleksandra Polkowska-Kramek, Worku Biyadgie Ewnetu, Pimnara Peerawaranun, Thao Mai Phuong Tran, Charles Nuttens, Ana Gabriela Grajales, Sazini Nzula, Bradford D. Gessner, Elizabeth Begier   +12 more
doaj   +1 more source

Immune Checkpoint Inhibitor–Related Myositis and Associated Triad Overlap Syndrome

Arthritis Care &Research, EarlyView.
Objective Immune checkpoint inhibitor (ICI) myositis is a rare but a highly morbid condition, particularly with the ICI myositis triad syndrome of myositis, myocarditis, and myasthenia gravis. We report the clinical characteristics of ICI myositis and all‐cause mortality in these patients.
Selene Rubino, Grant W. Cannon, Brian C. Sauer, Jorge Rojas, Gregory J. Stoddard, Gary A. Kunkel, Jessica A. Walsh, Bryant R. England, Joshua F. Baker, Tawnie J. Braaten   +9 more
wiley   +1 more source

Estimated Respiratory Syncytial Virus-Related Hospitalizations and Deaths Among Children and Adults in Spain, 2016–2019

Infectious Diseases and Therapy
Introduction Respiratory syncytial virus (RSV) causes a substantial disease burden among infants. In older children and adults, incidence is underestimated due to nonspecific symptoms and limited standard-of-care testing.
Mariana Haeberer, Robin Bruyndonckx, Aleksandra Polkowska-Kramek, Antoni Torres, Caihua Liang, Charles Nuttens, Maribel Casas, Francesca Lemme, Worku Biyadgie Ewnetu, Thao Mai Phuong Tran, Jessica E. Atwell, Cristina Mendez Diez, Bradford D. Gessner, Elizabeth Begier   +13 more
doaj   +1 more source

Signal Management: Updated Requirements of the EAEU Good Pharmacovigilance Practice

Безопасность и риск фармакотерапии, 2023
The Rules of Good Pharmacovigilance Practice of the Eurasian Economic Union (EAEU GVP Guideline) came into force in the EAEU Member States in 2017.
A. V. Matveev, A. E. Krasheninnikov, A. Yu. Zelinskaya   +2 more
doaj   +1 more source

Clinically important differences in the intensity of chronic refractory breathlessness [PDF]

, 2013
Context: Clinically important differences in chronic refractory breathlessness are ill defined but important in clinical practice and trial design.
Abernethy, Amy P., Bland, J. Martin, Currow, David C., Johnson, Miriam J., Oxberry, Stephen G.   +4 more
core   +2 more sources

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source