Results 91 to 100 of about 37,908 (274)
Advanced Science, EarlyView.This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui +14 more
wiley +1 more source
Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity
Advanced Science, EarlyView.We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu +17 more
wiley +1 more source
Advanced Science, EarlyView.This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang +12 more
wiley +1 more source
Traditional Uses, Phytochemistry, Pharmacology and Toxicology of Ruta graveolens L.: A Critical Review and Future Perspectives [PDF]
Ping Luo,1,2 Xu Feng,1,2 Shao Liu,1,2 Yueping Jiang1– 3 1Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, People’s Republic of China; 2National Clinical Research Center for Geriatric Disorders, Xiangya Hospital,
Jiang Y, Luo P, Feng X, Liu S
core +1 more source
, 1981 dissertationAn estimated one to two million accidental childhood poisonings occur yearly in the United States, primarily in children under five. The National Clearinghouse for Poison Control Centers (NCPCC) reported over 150,000 poisonings in 1978., 71 ...
Marvin, Lucinda Jo
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Risk Management and Healthcare Policy, 2021 Aklilu Tekeba,1 Yohanes Ayele,2 Belay Negash,3 Tigist Gashaw4 1Micheta Community Pharmacy, Daro Lebu Health Office, West Harerghe, Ethiopia; 2Department of Clinical Pharmacy, School of Pharmacy, College of Health and Medical Sciences, Hawassa University,
Tekeba A, Ayele Y, Negash B, Gashaw T
doaj
Advanced Science, EarlyView.Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang +32 more
wiley +1 more source
, 1988 dissertationGeriatric health care has witnessed the emergence of a new para-health professional, the informal caregiver. A caregiver is one "who attempts to meet the physiological and psychosocial needs of a frail and dependent elder." The role, or ...
Bartlome, Patricia
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Advanced Science, EarlyView.Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green +15 more
wiley +1 more source
, 1985 dissertationAn interpretation of medication education begins with the realization that education is not an autonomous self-regulating system but rather is a human creation complete with its own human motives, human goals, and human achievements.
Orlando, Patricia Lynn
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