Results 161 to 170 of about 37,908 (274)

Pharmacological Inhibition of FKBP51 Mitigates Early Life Adversity‐Induced Social Deficits in Male Mice

Advanced Science, EarlyView.
Early life adversity triggers persistent social subordination and brain‐wide molecular dysregulation. Pharmacological inhibition of the stress‐mediator FKBP51 during the adversity period prevents these long‐term deficits and restores normative social hierarchy.
Joeri Bordes, Xiuqi Ji, Serena Gasperoni, Choham Sudre‐Chinsky, Amirali Kalbasi, Daniela Harbich, Cornelia Flachskamm, Paula Fontanet, Sowmya Narayan, Manfred Uhr, Christian Namendorf, Camilla Bellone, Alon Chen, Felix Hausch, Juan Pablo Lopez, Mathias V. Schmidt   +15 more
wiley   +1 more source

The Effect of Melatonin Supplement on High Arterial Blood Pressure: An Overview from Clinicaltrials.gov

Journal of Multidisciplinary Healthcare
Ahmed M Ashour Pharmacology and Toxicology Department, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi ArabiaCorrespondence: Ahmed M Ashour, Pharmacology and Toxicology Department, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi ...
Ashour AM
doaj  

Retraction: Investigating new bilosomes for <i>ex vivo</i> skin deposition, <i>in vitro</i> characterization, and transdermal delivery of nimodipine. [PDF]

Nanoscale Adv
Chettupalli AK, Bukke SPN, Udom GJ, Saraswathi TS, Rahaman SA, Rai SN, Kavitha M, Boggula N, Goruntla N, Yadesa TM, Onohuean H.   +10 more
europepmc   +1 more source

Targeting DNGR‐1 with Fangchinoline Elevates Dendritic Cell Antigen Cross‐Presentation‐Mediated Antitumor Immunity in Melanoma

Advanced Science, EarlyView.
Fangchinoline is identified as a small‐molecule DNGR‐1 modulator that enhances dendritic‐cell cross‐presentation of tumor antigens. By engaging DNGR‐1 and activating Syk–Nox2 signaling, it promotes phagosomal ROS, antigen escape, MHC‐I presentation, and CD8+ T‐cell priming, thereby strengthening antitumor immunity and sensitizing tumors to PD‐1 ...
Yuan Liao, Zhenyang Ren, Jing Zhou, He Luo, Yuling Li, Dan Chen, Yuxiao Jiang, Canzhe Li, Mengyi Zheng, Anqi Li, Yao Wang, Yang Zhang, Dingye Wang, Yanjun Jiang, Jiangyong Gu, Biaoyan Du, Yafei Shi, Fang Liu, Jianyong Xiao, Kun Wang   +19 more
wiley   +1 more source

Correction: Licochalcone D reduces H₂O₂-induced SH-SY5Y cell neurotoxicity by regulating reactive oxygen species. [PDF]

Front Pharmacol
Kwak AW, Park S, Oh HN, Shim JH, Yoon G, Kim WK.   +5 more
europepmc   +1 more source

UBE2O Drives Immune Evasion and Radioimmunotherapy Resistance in Lung Cancer by Degrading CDKL1 to Induce PD‐L1 Transcription

Advanced Science, EarlyView.
UBE2O targets CDKL1 for the degradation to upregulate PD‐L1 expression and promotes resistance to radioimmunotherapy in lung cancer, supporting the potential of targeting UBE2O as a promising therapeutic strategy. ABSTRACT Resistance to radioimmunotherapy is one of the primary causes of treatment failure in lung cancer patients; however, the underlying
Huichan Xue, Xiaohua Jie, Zhiwei Liu, Ruoxin Fang, Shuo Wu, Xiaorong Dong, Shuangbing Xu   +6 more
wiley   +1 more source

Benzbromarone Analog SAR: Potent hURAT1 (SLC22A12) Inhibitors and Drug Transporter Interaction Studies

Drug Design, Development and Therapy
Promsuk Jutabha,1,2 Vijay Kumar,3 Naohiko Anzai,2,4 Peter J Rice,5,6 Janet W Lightner,6 Hitoshi Endou,7 Michael F Wempe3,8,9 1Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Samut Prakarn, 10540 ...
Jutabha P, Kumar V, Anzai N, Rice PJ, Lightner JW, Endou H, Wempe MF   +6 more
doaj  

Correction: Ultrasound assisted extraction enhances phytochemical profile and functional properties of moringa leaf extract with protection against gentamicin induced nephrotoxicity. [PDF]

Sci Rep
Shehata AM, Abdel-Hameed SM, Anter AF, Abdelsalam RR.   +3 more
europepmc   +1 more source

Optical Windows for Transcranial Brain Imaging in Living Mice: Skull Thinning, Clearing, and Beyond

Advanced Science, EarlyView.
Longitudinal, noninvasive in vivo imaging is crucial for studying brain physiology. Advances in transcranial optical windows and multiphoton microscopy have improved imaging depth, but their performance often deteriorates over time. This work investigated various transcranial window approaches and found that skull regrowth limits image quality.
Yiming Fu, Gewei Yan, Zhentao She, Yingzhu He, Kangqi Liu, Jianan Qu   +5 more
wiley   +1 more source

RETRACTED: Badr et al. Design and Evaluation of S-Protected Thiolated-Based Itopride Hydrochloride Polymeric Nanocrystals for Functional Dyspepsia: QbD-Driven Optimization, In Situ, In Vitro, and In Vivo Investigation. <i>Pharmaceuticals</i> 2023, <i>16</i>, 925. [PDF]

Pharmaceuticals (Basel)
Badr MY, Basim P, Hosny KM, Rizg WY, Naveen NR, Kurakula M, Alsulaimani F, Safhi AY, Sabei FY, Alissa M, Alamoudi AJ.   +10 more
europepmc   +1 more source