Results 11 to 20 of about 35,928 (231)

Infection Prevalence at a Tertiary Hospital in Hail, Saudi Arabia: A Single-Center Study to Identify Strategies to Improve Antibiotic Usage

Infection and Drug Resistance, 2023
Muteb Alanazi,1 Hassan Mohammed Alqahtani,1 Mohammad Khalid Alshammari,1 Raad Mohammed Alshammari,1 Jonaid Ahmad Malik,2,3 Sakeel Ahmed,4 Mir Aroosa,5 Mrunal Shinde,6 Tareq Nafea Alharby,1 Mukhtar Ansari,1 Arshad Hussain,1 Fahad F Alkhrshawy,7 ...
Alanazi M, Alqahtani HM, Alshammari MK, Alshammari RM, Malik JA, Ahmed S, Aroosa M, Shinde M, Alharby TN, Ansari M, Hussain A, Alkhrshawy FF, Anwar S   +12 more
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Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Antileishmanial Activity of Tamoxifen by Targeting Sphingolipid Metabolism: A Review

Clinical Pharmacology: Advances and Applications, 2022
Kaleab Alemayehu Zewdie, Haftom Gebregergs Hailu, Muluken Altaye Ayza, Bekalu Amare Tesfaye Department of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, Mekelle, EthiopiaCorrespondence: Kaleab Alemayehu Zewdie, Department of ...
Zewdie KA, Hailu HG, Ayza MA, Tesfaye BA
doaj  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Thioredoxin-Interacting Protein as a Novel Potential Therapeutic Target in Diabetes Mellitus and Its Underlying Complications

Diabetes, Metabolic Syndrome and Obesity, 2020
Dawit Zewdu Wondafrash,1 Asmelash Tesfay Nire’a,2 Gebrehiwot Gebremedihn Tafere,1 Desilu Mahari Desta,3 Demoze Asmerom Berhe,4 Kaleab Alemayehu Zewdie1 1Department of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, Mekelle ...
Wondafrash DZ, Nire'a AT, Tafere GG, Desta DM, Berhe DA, Zewdie KA   +5 more
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Wound Healing Activity of Opuntia ficus-indica Fixed Oil Formulated in a Self-Nanoemulsifying Formulation

International Journal of Nanomedicine, 2021
Abdulrahman E Koshak,1 Mardi M Algandaby,2,3 Mohammad I Mujallid,3 Ashraf B Abdel-Naim,4 Nabil A Alhakamy,5 Usama A Fahmy,5 Anas Alfarsi,5 Shaimaa M Badr-Eldin,5,6 Thikryat Neamatallah,4 Mohammed Z Nasrullah,4 Hossam M Abdallah,1,7 Ahmed Esmat8,9 ...
Koshak AE, Algandaby MM, Mujallid MI, Abdel-Naim AB, Alhakamy NA, Fahmy UA, Alfarsi A, Badr-Eldin SM, Neamatallah T, Nasrullah MZ, Abdallah HM, Esmat A   +11 more
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α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Correction to: Protective Effects of Trigonella foenum graecum L. Extract Against Cytotoxicity Induced by Cyclophosphamide on Ovarian Cancer (SKOV3) and Normal Cell Lines

Journal of Mazandaran University of Medical Sciences, 2018
Correction to: Protective Effects of Trigonella foenum graecum L. Extract Against Cytotoxicity Induced by Cyclophosphamide on Ovarian Cancer (SKOV3) and Normal Cell Lines     Mohammad Shokrzadeh1, Emran Habibi2, Niloofar Pourfoladchi3, Hamidreza ...
Mohammad Shokrzadeh, Emran Habibi, Niloofar Pourfoladchi, Hamidreza Mohammadi   +3 more
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