Results 111 to 120 of about 289,721 (318)

BLOC: Buildable and Linkable Organ on a Chip

Advanced Materials Technologies, EarlyView.
We developed a “Buildable and Linkable Organ on a Chip” (BLOC) that can construct diverse microphysiological systems (MPSs). The BLOC is standardized to the same size and has one of the functions of “Culture,” “Control,” or “Analysis.” Users can freely configure various MPSs, including developing perfusion, cytotoxicity analysis, and biochemical ...
Yusuke Kimura, Hiroki Hamaguchi, Kotaro Oyama, Tomoko G. Oyama, Atsushi Kimura, Yasuhiro Ohshima, Noriko S. Ishioka, Mitsumasa Taguchi   +7 more
wiley   +1 more source

Antioxidant Activity of Some Selected East Borneo Plants [PDF]

, 2015
The native plants of East Borneo the Costus specious (Koening) J.E. Smith stem, Lagerstroema spesiosa Pers leaf, Cerbera mangans L leaf, Vitis trifolia L fruit., Scurrula atropurpurea (Blume) Danser root, Brucea javanica (L.) Merr.
Ahmad, I. (Islamudin), Rijai, L. (Laode), Sulistiarini, R. (Risky)   +2 more
core  

Nanophotonic Strategies for Chiral Biosensing: Nanoparticles, Metasurfaces, Magneto‐Optical, and Quantum Approaches

Advanced Photonics Research, EarlyView.
Recent advances in nanophotonics‐based chiral biosensing approaches are comprehensively reviewed, highlighting key trends, advantages, and limitations of each technology. Special attention is given to emerging strategies that exploit magneto‐optical and quantum plasmonic phenomena to enhance sensitivity down to the level of a few molecules, or even a ...
Jorge Ricardo Mejía‐Salazar
wiley   +1 more source

Evaluating comfort measures for commonly performed painful procedures in pediatric patients. [PDF]

, 2018
Introduction: Management of pediatric pain from medical procedures is of great importance for improving both patient care and experience. In this study, we investigated methods of managing acute pain in infants and children by studying the correlation ...
Daskalakis, Constantine, Dastgheyb, Sana, Fishlock, Keith, Kessel, Jami, Rosen, Paul   +4 more
core   +1 more source

NNMT Orchestrates Metabolic‐Epigenetic Reprogramming to Drive Macrophage‐Myofibroblast Transition in Hypertrophic Scarring

Advanced Science, EarlyView.
In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine‌ (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong, Weinan Guo, Yuxuan Qian, Wenyan Jin, Xiaozhen Li, Jingyuan Yang, Qingrong Ni, Shuang Wu, Fanni Li, Hua Wang, Chunying Li, Hong Cai   +11 more
wiley   +1 more source

Garuda 5 (khyung lnga): Ecologies of Potency and the Poison-Medicine Spectrum of Sowa Rigpa’s Renowned ‘Black Aconite’ Formula [PDF]

, 2019
This article focuses on ethnographic work conducted at the Men-Tsee-Khang (Dharamsala, India) on Garuda 5 (khyung lnga), a commonly prescribed Tibetan medical formula.
van der Valk, Jan M. A.
core   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Monascus purpureus Red Yeast Rice: A Review of the in vitro and in vivo Pharmacological Activities, Studies in Humans, and Case Reports

Clinical Pharmacology: Advances and Applications
Resha Resmawati Shaleha,1,2,* Anna Yuliana,3,* Saeful Amin,2,* Jutti Levita,4,5,* Sri Adi Sumiwi4,5,* 1Doctoral Program in Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia; 2Faculty of ...
Shaleha RR, Yuliana A, Amin S, Levita J, Sumiwi SA   +4 more
doaj  

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Identifying Potential Human Monoacylglycerol Lipase Inhibitors from the Phytoconstituents of Morinda Citrifolia L. Fruits by in silico Pharmacology and in vitro Study

Journal of Experimental Pharmacology
Asman Sadino,1,2,* Nyi Mekar Saptarini,3 Jutti Levita,4,* Dwi Syah Fitra Ramadhan,5 Adryan Fristiohady,6 Supat Jiranusornkul7 1Doctoral Program in Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, West Java, 45363, Indonesia ...
Sadino A, Saptarini NM, Levita J, Ramadhan DSF, Fristiohady A, Jiranusornkul S   +5 more
doaj