Results 161 to 170 of about 289,721 (318)

Biopharmaceutics, Pharmacy and Pharmacology [PDF]

, 2005
登美 斉俊, 細谷 健一
core   +1 more source

HSP70 Interactome‐Mediated Proteolysis Targeting Chimera (HSP70‐PROTAC) for Ferroptosis‐Driven Cancer Treatment

Advanced Science, EarlyView.
This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong, Yulong Li, Hui Liang, Zumei Wu, Shiqun Wang, Yichao Wang, Jieyu Xu, Yanning Lan, Maohua Cai, Guangzhao Pan, Haiyan Yang, Kai Miao, Zhe‐Sheng Chen, Fangfang Tao, Xuelei Ma, Jiang‐Jiang Qin   +15 more
wiley   +1 more source

Biopharmaceutics, Pharmacy and Pharmacology [PDF]

, 2006
登美 斉俊, 立川 正憲, 細谷 健一   +2 more
core   +1 more source

ITGB1 Regulates Triple‐Negative Breast Cancer Development by Modulating the Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumorigenesis and metastasis are frequently attributed to the intricate interplay between cancer cells and the tumor microenvironment (TME). Comprehending the mechanisms and key regulators of cancer‐immune crosstalk in the TME is imperative for developing efficacious immunotherapy.
Nuozi Song, Siqi Chen, Lei Wang, Jessica Dang, Xu Cao, Stephanie Singh, Lu Yang, Jinhui Wang, Steven T. Rosen, Yingyu Wang, Chun‐Wei D. Chen, Cheng Zhang, Mingye Feng   +12 more
wiley   +1 more source

One Step Ahead in Realizing Pharmacogenetics in Low- and Middle-Income Countries: What Should We Do?

Journal of Multidisciplinary Healthcare
Yudisia Ausi,1,2 Melisa Intan Barliana,2,3 Maarten J Postma,3,4 Auliya A Suwantika3,5 1Doctor Program in Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, Indonesia; 2Department of Biological Pharmacy, Faculty of Pharmacy, Universitas ...
Ausi Y, Barliana MI, Postma MJ, Suwantika AA   +3 more
doaj  

Molecular Pharmacology at the Crossroads of Precision Medicine. [PDF]

Curr Issues Mol Biol
Nicolae AC, Dumitrescu IB, Drăgoi CM.
europepmc   +1 more source

Opportunities and Challenges of Using Big Data to Detect Drug-Drug Interaction Risk [PDF]

, 2019
Chasioti D., Institute of Medicine Committee on Data Standards for Patient Safety   +1 more
core   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Impact of Lipids on Insulin Resistance: Insights from Human and Animal Studies

Drug Design, Development and Therapy
Rani Yulifah Elkanawati,1,* Sri Adi Sumiwi,2 Jutti Levita2,* 1Master Program in Pharmacy, Faculty of Pharmacy, Padjadjaran University, Jawa Barat, West Java, 45363, Indonesia; 2Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy,
Elkanawati RY, Sumiwi SA, Levita J
doaj  

RETRACTED: Shoaib et al. Neuroprotective Effects of Dried Tubers of <i>Aconitum napellus</i>. <i>Plants</i> 2020, <i>9</i>, 356. [PDF]

Plants (Basel)
Shoaib A, Siddiqui HH, Dixit RK, Siddiqui S, Deen B, Khan A, Alrokayan SH, Khan HA, Ahmad P.   +8 more
europepmc   +1 more source