Results 181 to 190 of about 289,721 (318)

The Journal of Pharmacy and Pharmacology 2005

, 2006
David S. Jones
semanticscholar   +1 more source

Discovery of SKP2‐Recruiting PROTACs for Target Protein Degradation

Advanced Science, EarlyView.
Based on the SKP2‐targeting ligand SL1, we designed non‐covalent PROTACs by linking it with the BRD4 inhibitor JQ1 and the AR antagonist AL through a linker. These PROTACs successfully induced the ubiquitination of BRD4 and AR, followed by proteasome‐mediated degradation.
Guanjun Dong, Aima Huang, Ziqing Zhao, Bikai Lai, Xin Pan, Huiyu Yang, Xiaohan Xu, Tianwei Wang, Fangchen Zhao, Zhimin Zhang, Yongbo Xue, Guanjun Deng, Wenbin Deng, Jianwei Chen   +13 more
wiley   +1 more source

Marmelosin Protects Against Metabolic Disturbances in High-Fat Diet and Streptozotocin-Induced Diabetes

Diabetes, Metabolic Syndrome and Obesity
Sattam Khulaif Alenezi,1 Khalid S Alharbi,1 Tariq G Alsahli,2 Reem ALQahtani,3 Muhammad Afzal,4 Krishana Kumar Sharma,5 Nadeem Sayyed6 1Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraydah, Al Qassim, 51452, Saudi ...
Alenezi SK, Alharbi KS, Alsahli TG, ALQahtani R, Afzal M, Sharma KK, Sayyed N   +6 more
doaj  

Impact of short educational videos on learning and retention in undergraduate pharmacology education: a cross-sectional study. [PDF]

BMC Med Educ
Wali SM.
europepmc   +1 more source

Targeting the CMKLR1‐Mediated Signaling Rebalances Immunometabolism State in Middle‐Age Testicular Macrophages

Advanced Science, EarlyView.
In middle age, testicular CMKLR1⁺ macrophages exhibited a pro‐inflammatory immunometabolic profile, mediated by adipose signals associated with high BMI. However, inhibition of CMKLR1 signaling, either through Cmklr1 genetic ablation or treatment with a CMKLR1 antagonist peptide, can reverse this phenotype.
Zhendong Zhu, Feifei Du, Yang Liu, Jinchunzi Yang, Lei Ge, Tianxia Xiao, Mengxia Li, Jie Chen, Jia Tang, Yali Yang, Jian V. Zhang   +10 more
wiley   +1 more source

Correction: Correlation analysis between plasma concentration of nilotinib and clinical efficacy and safety in patients with chronic myeloid leukemia: a single-center retrospective cohort study. [PDF]

Front Pharmacol
Liu Y, Lin T, Zhao B, Li Y, Zheng P.
europepmc   +2 more sources

RETRACTED: Abo Mansour et al. The Potential Neuroprotective Effect of Thymoquinone on Scopolamine-Induced In Vivo Alzheimer's Disease-like Condition: Mechanistic Insights. <i>Molecules</i> 2023, <i>28</i>, 6566. [PDF]

Molecules
Abo Mansour HE, Elberri AI, Ghoneim ME, Samman WA, Alhaddad AA, Abdallah MS, El-Berri EI, Salem MA, Mosalam EM.   +8 more
europepmc   +1 more source

Resolvin D5 Inhibits CXCL8 Expression in Colonic Epithelial Cells Through Activating GPR101 to Impede Neutrophil Recruitment and Consequently Alleviate Ulcerative Colitis

Advanced Science, EarlyView.
RvD5 effectively alleviates UC by inhibiting STAT1 signaling to reduce CXCL8 expression in colonic epithelial cells via activation of GPR101, which subsequently decreases the infiltration of neutrophils in the colonic mucosal epithelium. Epimedin A1, a natural allosteric inhibitor of 5‐LOX, demonstrates potential as a therapeutic agent for UC by ...
Pengxiang Guo, Yilei Guo, Yanrong Zhu, Ke Yan, Yulai Fang, Jiafeng Zhang, Yue He, Zhifeng Wei, Yufeng Xia, Yue Dai   +9 more
wiley   +1 more source

RETRACTED: Kola-Mustapha et al. Network Pharmacology and Molecular Modeling to Elucidate the Potential Mechanism of Neem Oil against <i>Acne vulgaris</i>. <i>Molecules</i> 2023, <i>28</i>, 2849. [PDF]

Molecules
Kola-Mustapha AT, Raji MA, Adedeji O, Ambrose GO.   +3 more
europepmc   +1 more source

Clinical Pharmacy Education and Pharmacology

Japanese Journal of Pharmacology, 1998
openaire   +1 more source