Results 241 to 250 of about 289,721 (318)

Open-Access Web-Based Gamification in Pharmacology Education for Medical Students: Quasi-Experimental Study.

JMIR Med Educ
Aloum L, Ibrahim H, Rajasekaran SK, Alefishat E.   +3 more
europepmc   +1 more source

Retraction notice to "Evaluation of <i>Sechium edule</i> fruit attenuation impact on the cardiomyopathy of the STZ-induced diabetic rats" [Heliyon 10 (2024) e30440]. [PDF]

Heliyon
Mohammad FS, Das U, Samanta SK, Irfan Z, Gopinath SCB, Mostafa MAH, Al-Haidari RA, Abdellatif AAH, Shehata AM, Gouda MM.   +9 more
europepmc   +1 more source

Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling

Advanced Science, EarlyView.
Activation of microglial G protein–coupled receptor 35 (GPR35) by L‐kynurenic acid (L‐Kyna) initiates a platelet‐derived growth factor A (PDGFA)–dependent phosphoinositide 3‐kinase–protein kinase B (PI3K–AKT) signaling cascade that dampens hippocampal neuroinflammation, thereby restraining epileptogenesis, lowering seizure susceptibility, and ...
Qi Wang, Tingting Qu, Qibing Sun, Ran Li, Junfei Dong, Yuming Du, Ziyin Xuan, Lei Wang, Hanli Li, Jianyun Sun, Fangliang Chen, Jinshuai Liu, Zifan Yang, Jianxiang Lei, Qian Yang, Bin Wang, Zhiming Zhou, Yu Wang   +17 more
wiley   +1 more source

Network pharmacology and molecular docking investigation of <i>Curcuma xanthorrhiza</i> Roxb. rhizome with the mechanisms underlying as the potential drug of eczema treatment. [PDF]

J Adv Pharm Technol Res
Pratama YA, Marhaeny HD, Winarto S, Palmado IA, Widyananda MH, Rahmadi M, Taher M, Hasan AA, Kleuser B, Khotib J.   +9 more
europepmc   +1 more source

miR‐135a‐5p Is a Promising Target to Prevent the Glomerulosclerosis Associated with Podocyte Developmental Toxicity in Offspring Induced by Prenatal Dexamethasone Exposure

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) programs persistent podocyte developmental injury and adult glomerulosclerosis. Mechanistically, glucocorticoid receptor (GR) binds the miR‐135a‐5p promoter and recruits the histone acetyltransferase p300, increasing promoter histone acetylation and sustaining miR‐135a‐5p expression. Elevated miR‐135a‐5p suppresses
Xiaoqi Zhao, Haiyun Chen, Yanan Zhu, Zhiping Xia, Hangyuan He, Yutang Liu, Tianshu Yang, Hui Wang, Ying Ao   +8 more
wiley   +1 more source

Multimodal Layer‐Crossing Interrogation of Brain Circuits Enabled by Microfluidic Axialtrodes

Advanced Science, EarlyView.
The study introduces a flexible microfluidic axialtrode that integrates optical, electrical, and chemical modalities within a single polymer fiber. By redistributing electrodes and fluidic channels along the fiber axis via angled cleaving, it enables simultaneous optogenetic stimulation, electrophysiological recording, and drug delivery across brain ...
Kunyang Sui, Neela K. Codadu, Daman Rathore, Guanghui Li, Marcello Meneghetti, Anders L. Bøcker, Rune W. Berg, Rob C. Wykes, Christos Markos   +8 more
wiley   +1 more source

Time to Stop Correcting Total Calcium. [PDF]

J Pediatr Pharmacol Ther
Christensen ML.
europepmc   +1 more source

ZBTB21 Is a Dual Suppressor of Pyroptosis and MHC‐I Antigen Presentation That Promotes Tumor Immune Evasion

Advanced Science, EarlyView.
ZBTB21 is a transcription factor that epigenetically suppresses pyroptosis and MHC‐I antigen presentation, enabling tumor immune evasion. Genetic ablation of ZBTB21 activates pyroptotic cell death and enhances antigen presentation, recruiting CD8+ T cells to overcome immune checkpoint blockade resistance.
Lei Zhao, Linlin Sheng, Jianhao Qiu, Junjie Ma, Kai Jin, Binggong Zhao, Tianrun Miao, Jing Chen, Yehong Li, Zhan Zhang, Dongfeng Sun, Yongmeng Li, Hui Tian   +12 more
wiley   +1 more source

Retraction notice to "<i>In vitro</i> and <i>In vivo</i> study targeting the development of Unani Antidermatophytic Cream: Implication of Herbal Formulations in Treatment of Dermatophytosis" [Heliyon 9 (2023) e16154]. [PDF]

Heliyon
Anjum H, Sofi G, Shahwan M, Khan MS, Shamsi A, Shamsi S.   +5 more
europepmc   +1 more source