Results 61 to 70 of about 659,631 (258)

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Undergraduate pharmacy students’ perceptions of research in general and attitudes towards pharmacy practice research

International Journal of Pharmacy Practice, 2012
AbstractObjectivesTo investigate pharmacy students’ perceptions of research in general and attitudes towards pharmacy practice research (PPR) at each stage of the undergraduate programme and determine any relationship between perceptions and attitudes, and to validate a measure of attitudes towards PPR in an Australian cohort of pharmacy students ...
Vicky S, Kritikos, Steven, Carter, Rebekah J, Moles, Ines, Krass   +3 more
openaire   +2 more sources

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

A mixed-methods study investigating the potential and challenges of generic substitution of controlled substances in community pharmacies

Exploratory Research in Clinical and Social Pharmacy
Background: Using generics became an established practice. Studies about dispensing practices of generic controlled substances are scarce. Objective: We investigated dispensing practices of generic controlled substances compared to non-controlled ...
I.M. Keller, J.M. Alexa, M.W. Meier, S.S. Allemann   +3 more
doaj   +1 more source

Characteristics of Critical Care Pharmacy Services in Saudi Arabia

Journal of Multidisciplinary Healthcare, 2023
Nadia H Ismail,1,2,* Abdullah M Alhammad,3,* Abdulrahman I Alshaya,4– 6 Nada Alkhani,7 Ahmed O Alenazi,6,8 Ohoud Aljuhani9 1Department of Clinical Pharmacy Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal ...
Ismail NH, Alhammad AM, Alshaya AI, Alkhani N, Alenazi AO, Aljuhani O   +5 more
doaj  

Factors influencing pharmacy students’ attitudes towards pharmacy practice research and strategies for promoting research interest in pharmacy practice

Pharmacy Practice, 2015
To (1) investigate the relationships between students' characteristics and their (a) perceptions of research in general and (b) attitudes towards pharmacy practice research; (2) identify strategies that could be used by pharmacy educators to promote research interest in pharmacy practice; and (3) identify perceived barriers to the pursuit or completion
Kritikos, Vicky S., Saini, Bandana, Carter, Stephen, Moles, Rebekah J., Krass, Ines   +4 more
openaire   +4 more sources

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Integrated Pharmacy Research and Practice

Integrated Pharmacy Research and Practice, 2012
Adam Todd,1 Jonathan Ling21Wolfson Research Institute, School of Medicine and Health, Queen’s Campus, Durham University, Stockton-on-Tees, UK; 2Faculty of Applied Sciences, University of Sunderland, Sunderland, UKBy 2014, the worldwide annual spend
Todd A, Ling J
doaj