Results 121 to 130 of about 696,578 (342)

Barnes Hospital Bulletin [PDF]

, 1977
https://digitalcommons.wustl.edu/bjc_barnes_bulletin/1143/thumbnail ...

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Metabolic Reprogramming of T Cells by Dual UCP2 and IL‐17 Blockade Enhances Immunity Against Pancreatic Cancer

Advanced Science, EarlyView.
This study demonstrates that dual UCP2/IL‐17 blockade reprograms T‐cell metabolism to overcome PDAC immunosuppression. Genipin‐mediated UCP2 inhibition enhances CD8⁺ T‐cell IFN‐γ via IL‐12R/STAT4/mTOR signaling and mitochondrial OXPHOS. Combined IL‐17 depletion amplifies Tc1/Th1 responses, reduces MDSCs, and prolongs survival in PDAC models ...
Chuan‐Teng Liu, Chun‐Chieh Yeh, Tsai‐Chen Wu, Chia‐Hsin Lin, Yi‐Ting Kuo, Yoichiro Iwakura, Yuan‐Ji Day, Charles Drake, Vedran Radojcic, Ying‐Chyi Song, Heng‐Hsiung Wu, Hung‐Rong Yen   +11 more
wiley   +1 more source

Managing Medicaid Pharmacy Benefits: Current Issues and Options [PDF]

, 2011
Examines issues and considerations for state reforms of Medicaid prescription drug reimbursement, pharmacy management, and cost sharing and other best practices for realizing ...
Robin Rudowitz, Sandy Kramer, Vernon K. Smith   +2 more
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What Patients Want: Preferences Regarding Hospital Pharmacy Services

The Canadian Journal of Hospital Pharmacy, 2013
The role of hospital pharmacists has evolved over the past couple of decades from preparation and distribution of medications to active involvement in health care teams, through identification and resolution of patients' medication-related issues in an effort to improve patient outcomes.
Odette, Gould, Paula, Buckley, Douglas, Doucette   +2 more
openaire   +3 more sources

A Quantum Framework for Protein Binding‐Site Structure Prediction on Utility‐Level Quantum Processors

Advanced Science, EarlyView.
This study presents a hybrid quantum‐classical framework for accurate prediction of protein structures on utility‐level quantum processors. We evaluate the practical application of the Variational Quantum Eigen‐solver (VQE) in protein structure prediction and demonstrate its superiority over state‐of‐the‐art deep learning methods in molecular docking ...
Yuqi Zhang, Yuxin Yang, William Martin, Kingsten Lin, Zixu Wang, Cheng‐Chang Lu, Weiwen Jiang, Ruth Nussinov, Joseph Loscalzo, Qiang Guan, Feixiong Cheng   +10 more
wiley   +1 more source

IMPLEMENTATION OF THEORY OF CONSTRAINT ON WAITING TIME OF PRESCRIPTION SERVICE

Jurnal Administrasi Kesehatan Indonesia, 2019
Background: Medical services provided within the Indonesian National Health Insurance programme or Jaminan Kesehatan Nasional (JKN) have been continuously improving for the past several years.
Alissa Sita Pertiwi, Thinni Nurul Rochmah   +1 more
doaj   +1 more source

The Pivotal Role of GR‐CAR Pathway in Fetal Programming of Hepatic Cytochrome P450 3A Alteration in Adulthood

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) persistently upregulates hepatic CYP3A1/CYP2B1 in offspring via glucocorticoid receptor (GR) activation. In vivo and in vitro studies show GR promotes P300/CBP binding to the constitutive androstane receptor (CAR) promoter, sustaining histone acetylation (H3K9/K27ac) and enhancing CYP expression. The GR–CAR pathway
Xiaoxiang Sun, Jie Liu, E Xiang, Xia Li, Xuerong Yan, Yuxi Wang, Feng Li, Hao Kou, Hui Wang, Yu Guo   +9 more
wiley   +1 more source

Validation of a Scorecard of Quality and Activity Indicators for Telepharmacy Pharmaceutical Care Services in Spanish Hospitals

Integrated Pharmacy Research and Practice
Luis Margusino-Framiñán,1 Olatz Ibarra-Barrueta,2 Irene Mangues-Bafalluy,3 Emilio Monte-Boquet,4 Patricia Sanmartín-Fenollera,5 Amparo Talens-Bolós,6 Ramón Morillo-Verdugo7 1Pharmacy Department, Research Group of Hospital Pharmacy, a Coruña Biomedical ...
Margusino-Framiñán L, Ibarra-Barrueta O, Mangues-Bafalluy I, Monte-Boquet E, Sanmartín-Fenollera P, Talens-Bolós A, Morillo-Verdugo R   +6 more
doaj  

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science, EarlyView.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
wiley   +1 more source

The cost of the district hospital : a case study from Malawi [PDF]

The author analyzes the cost to the Ministry of Health of providing district health services in Malawi, with an emphasis on the cost of the district hospital.
Mills, A.J.
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