Results 251 to 260 of about 557,364 (341)

Postsurgical infection with carbapenemase-producing Enterobacterales in a 45-year-old woman. [PDF]

CMAJ
Leung E, Fattouh R, Verway M, Tan C.
europepmc   +1 more source

Biomarker‐Based Prediction of OATP1B1 Activity in Clinical Routine—Investigating Coproporphyrins as Markers for Drug–Drug–Gene Interactions

Clinical Pharmacology &Therapeutics, EarlyView.
Coproporphyrin I (CPI) is an established endogenous biomarker for detecting drug–drug interactions (DDIs) involving the hepatic uptake transporter Organic Anion Transporting Polypeptide 1B1 (OATP1B1, gene SLCO1B1). While CPI has been extensively studied in healthy volunteers using controlled pre‐ and post‐OATP1B1‐inhibitor sampling, its applicability ...
Leila Potzel, Anina Zumtaugwald, Anna Bollinger, Chiara Jeiziner, Kurt E. Hersberger, Florine Wiss, Markus L. Lampert, Samuel S. Allemann, Henriette E. Meyer zu Schwabedissen, Céline K. Stäuble   +9 more
wiley   +1 more source

Ruxolitinib Pharmacokinetics and Exposure–Toxicity Relationship in Hematologic Malignancies and Immune‐Mediated Diseases: A Prospective Observational Study

Clinical Pharmacology &Therapeutics, EarlyView.
Ruxolitinib pharmacokinetics (PK) has been characterized in clinical trials but remains poorly documented in real‐world practice. This project aimed to investigate ruxolitinib PK in routine clinical practice, identify factors driving its variability, and explore exposure–response relationships to assess the potential role of therapeutic drug monitoring.
Jérémie Tachet, Sara C. Meyer, Francesco Grandoni, Emmanuel Haefliger, Monika Nagy‐Hulliger, Jörg P. Halter, Jakob R. Passweg, David Haefliger, Carine Bardinet, Laurent A. Decosterd, Monia Guidi, François R. Girardin   +11 more
wiley   +1 more source

Exploring Research Capacity and Engagement Drivers Among Hospital Pharmacy Professionals: A Mixed Methods Study. [PDF]

Health Sci Rep
Al-Jabr H, McAleer S, Campbell P, Gulshan Tajuria, White S, Mallen C, Lambley-Burke R, Helliwell T.   +7 more
europepmc   +1 more source

Repurposing Registries: Completeness of Real‐World Data for Regulatory and HTA Purposes in Three Cancer‐Focused Registries

Clinical Pharmacology &Therapeutics, EarlyView.
Despite developments in supporting the identification and selection of fit‐for‐purpose registries, a translational gap remains between the original purposes of clinically focused registries and their current and future expected use in policymaking. This study aimed to assess the extent to which cancer‐focused registries collect essential data elements ...
Manon C. Wilpshaar, Doranne Hilarius, Luisa Prada, Ansgar Weltermann, Christine Leopold   +4 more
wiley   +1 more source

Examining public perceptions of cardiovascular disease risk screening programs in community pharmacies: a mixed-methods study. [PDF]

BMC Public Health
Alharbi S, Almalki R, Almajnooni S, Alsulami D, Alotaibi A.   +4 more
europepmc   +1 more source

Integrating Circular Economy and Lean Management: A Strategic Framework for Sustainable Business Transformation

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This study investigates the integration of circular economy (CE) and lean management (LM) as a strategic approach for enhancing corporate efficiency and sustainability. While CE emphasizes resource circularity, LM focuses on waste elimination and value maximization in production processes.
Pedro Carmona Marques, João Reis, Wesley Douglas Oliveira Silva   +2 more
wiley   +1 more source

Demographic, Geographic, and Temporal Patterns of Adult Dental Emergency Presentations in Arad County, Western Romania. [PDF]

Healthcare (Basel)
Negru MC, Banta AM, Voicu M, Nica DV, Talpoș-Niculescu IC, Olariu I.   +5 more
europepmc   +1 more source

Relational Capital and Sustainable Development in Developing Economies: A Systematic Review of Pathways, Practises and Impacts

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This study critically examines the role of relational capital (RC) in shaping the sustainable development of small and medium‐sized enterprises (SMEs). Although RC is widely recognised as a strategic resource, existing evidence remains fragmented, context‐dependent and theoretically underdeveloped.
Rana Kayyal, Ali Meftah Gerged
wiley   +1 more source

The Subjective Assessment Paradox in Health Literacy: Implications for Intervention Design in Primary Care Settings. [PDF]

Health Sci Rep
Qingfei K, Wen X.
europepmc   +1 more source