Results 301 to 310 of about 5,631,315 (366)

Selective Phosphorylation of Phenols and Benzenediols by the Kinase PsiK and Variants Thereof

Angewandte Chemie, EarlyView.
PsiK from Psilocybe cubensis phosphorylates a diverse set of substituted phenols and benzenediols beyond its native substrate. High‐throughput screening of active site mutant libraries using DESI‐MS enabled protein engineering of PsiK, further expanding its substrate scope.
Ahram Kim, Nicolás M. Morato, Prabir Saha, Pascal N. Eyimegwu, Aqeel A. Niyaz, Rui Huang, R. Graham Cooks, Ryan M. Phelan, Jared C. Lewis   +8 more
wiley   +2 more sources

Cluster-Randomized Trial to Evaluate a Centralized Clinical Pharmacy Service in Private Family Medicine Offices. [PDF]

Circ Cardiovasc Qual Outcomes, 2018
Carter BL, Levy B, Gryzlak B, Xu Y, Chrischilles E, Dawson J, Vander Weg M, Christensen A, James P, Polgreen L.   +9 more
europepmc   +1 more source

The feasibility of providing community pharmacy-based services for alcohol misuse: a literature review

, 2009
Margaret Watson, Alison Blenkinsopp
openalex   +1 more source

Thermodynamics of Water Displacement from Binding Sites and its Contributions to Supramolecular and Biomolecular Affinity

Angewandte Chemie, EarlyView.
The affinity between a guest and a macrocyclic host depends strongly on the water encapsulated inside the host cavity, with free‐energy variations on the order of 20 kcal mol−1 being possible even in the absence of direct host‐guest interactions. This conclusion–which contrasts alternative views–can be drawn from molecular dynamics simulations for the ...
Jeffry Setiadi, Frank Biedermann, Werner M. Nau, Michael K. Gilson   +3 more
wiley   +2 more sources

Evaluation of a cardiovascular disease opportunistic risk assessment pilot ('Heart MOT' service) in community pharmacies

, 2009
John Horgan, Alison Blenkinsopp, Richard J. McManus   +2 more
openalex   +1 more source

Nickel‐Catalyzed Suzuki–Miyaura Cross‐Coupling Reaction of Aliphatic Alcohol Derivatives

Angewandte Chemie, EarlyView.
A nickel‐catalyzed Suzuki–Miyaura coupling reaction of aliphatic mesylates is reported. This reaction provides a strategy for late‐stage functionalization of bioactive compounds that have high F(sp3). Preliminary mechanistic experiments confirm a stereoablative reaction outcome, consistent with alkyl radical intermediates.
Chloe D. Wong, Lauren C. Bradford, Nadia Hirbawi, Elizabeth R. Jarvo   +3 more
wiley   +2 more sources

Trigonal Planar Bis(carbene)Cu(I) Complexes Enable Divergent H2 Activation with H2O for Accelerated Olefin Hydrogenation

Angewandte Chemie, EarlyView.
Trigonal planar naphthyridine‐bis(carbene)Cu(I) alkyl, hydroxide, and ethoxide complexes promote a divergent mechanism of H2 activation for the rare catalytic hydrogenation of unactivated alkenes at mild conditions at copper. Abstract CuH‐catalyzed olefin hydrogenation is rare compared to those of carbonyl‐derived substrates. Olefin insertion into Cu–H
Evan A. Patrick, Shaama Mallikarjun Sharada, Anya Zoraster, Jeremy D. Erickson, David E. Ryan, R. Morris Bullock, Ba L. Tran   +6 more
wiley   +2 more sources

Is a Malleable Active Site Loop the Key to High Substrate Promiscuity? Hybrid, Biocatalytic Route to Structurally Diverse Taxoid Side Chains with Remarkable Dual Stereocontrol

Angewandte Chemie, EarlyView.
A highly stereoselective, dynamic reductive kinetic resolution (DYRKR) entry into myriad Taxotere‐like side chains with Clostridium acetobutylicum alcohol dehydrogenase (CaADH) enzyme is reported. Follow‐on cross couplings expand the structural diversity of the library (36 total examples).
Gaurav P. Kudalkar, Florian Leidner, Nivesh Kumar, Jared L. Hass, Peter Madzelan, Douglas R. Powell, Victor W. Day, Pierre Le Magueres, Joseph D. Ferrara, Lee M. Daniels, Akihito Yamano, Sho Ito, Wei Niu, Helmut Grubmüller, Mark A. Wilson, David B. Berkowitz   +15 more
wiley   +2 more sources

Abridging the 22‐Item Sino‐Nasal Outcome Test (SNOT‐22) in People With Cystic Fibrosis: Limiting Survey Burden

International Forum of Allergy &Rhinology, EarlyView.
Haidee Chen, Jakob L. Fischer, Tristan D. Tibbe, Ahmad R. Sedaghat, Ethan J. Han, Jess C. Mace, Jeremiah A. Alt, Todd E. Bodner, Naweed I. Chowdhury, Yuqing A. Gao, Peter H. Hwang, Ashoke Khanwalkar, Adam J. Kimple, Jivianne T. Lee, Douglas A. Li, Meghan Norris, Jayakar V. Nayak, Cameran Collins, Zara M. Patel, Katie Phillips, Katie Poch, Rodney J. Schlosser, Kristine A. Smith, Zachary M. Soler, Jeffrey D. Suh, Grant A. Turner, Marilene B. Wang, Anne Getz, Ashleigh Halderman, Sei Chung, Jeremy P. Tervo, Jonathan B. Overdevest, Ryan A. Cotter, Milene T. Saavedra, Jennifer L. Taylor‐Cousar, Myung‐Shin Sim, Daniel M. Beswick   +36 more
wiley   +1 more source