Results 131 to 140 of about 14,775,705 (255)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Phase Transition Dynamics of Phase Change Material in the Grille-Capsule Packed Channel

Chemical Engineering Transactions
Phase change thermal energy storage technology, with its high energy storage density and near-isothermal heat release characteristics, serves as an effective solution to address the intermittency and fluctuation issues in solar energy utilization ...
Haonan Jia, Yuhang Tian, Jian Yang, Qiuwang Wang   +3 more
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

COOPERANT: A High-Performance CSP Volumetric Receiver Coupled With Hybrid TES for Next Generation Power Cycles

SolarPACES Conference Proceedings
Concentrated Solar Power (CSP) enables stable, dispatchable electricity generation through an integrated Thermal Energy Storage (TES) system, but current molten salt-based configurations are limited to ~565ºC, constraining efficiency and system ...
Antonio Avila-Marin, Jesus Fernandez Reche, Dimitrina Lang, Anabel Palacios, William Delgado, Adina Hochuli, Marcella Paula, Juliana Rodrigues, Zafer Ure, Sandro Gianella, Gabriele Impellizzeri, Arturo Sanchez-Ramos, Patricia Royo   +12 more
doaj  

Synthesis and temperature control performance of TBAB/TBAHSO4 hydrate composite phase change material

Gongneng cailiao yu qijian xuebao
The cold energy storage technology based on phase change material (PCM) has received a lot of attention for its ability to effectively reduce carbon emissions compared to traditional refrigerated transport methods.
Lianxin LOU, Jing WEN, Mingzhao YANG, Yan KOU, Ying TIAN   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Low temperature paraffin phase change emulsions

, 2022
S.98-106A Phase Change Slurry (PCS) is a multifunctional fluid consisting of a Phase Change Material (PCM) and a carrier fluid. PCSs can store or transfer amounts of thermal energy by using both the sensible heat capacity of the carrier fluid and that of
Dötsch, C., Pollerberg, Clemens, Huang, L.   +2 more
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Grayscale photolithography with phase change material photomasks

, 2017
Here we report a grayscale photolithography technique using phase change materials, by inducing a multi-level refractive-index-changing phase-transition with femtosecond pulses.
Huang, Kevin Chung-Che, Yuan, Guanghui, Ang, S.S., Zheludev, Nikolai, Kiang, Kian, Sun, Kai, Teng, Jinghua, Wang, Qian, Rogers, Edward, Gholipour, Behrad   +9 more
core   +1 more source

Tunable hyperbolic polaritons with plasmonic phase-change material In3SbTe2

Nanophotonics
Hyperbolic polaritons that originate from the extreme optical anisotropy in van der Waals (vdW) crystals have gained much attention for their potential in controlling nanolight.
Lu Dunzhu, Zeng Ying, Yan Qizhi, Chen Qiyu, Ma Weiliang, Luo Xiao, Xu Ming, Yang Xiaosheng, Li Peining   +8 more
doaj   +1 more source