Results 171 to 180 of about 1,679,672 (353)

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Electron-deficient multicenter bonding in phase change materials: A chance for reconciliation

open access: yes
In the last years, a controversy has been raised regarding the nature of the chemical bond in phase change materials. Two bonding models have claimed to be able to explain their extraordinary properties: the metavalent bonding model and the hypervalent ...
Ángel, Vegas   +3 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Effect of Graphene Nanoplatelet Size on the Thermal Properties of Bio-Based Phase-Change Materials for Thermal Energy Storage

open access: yes
The rising environmental impact of building energy consumption has intensified the demand for sustainable energy solutions. Latent heat thermal energy storage (LHTES) using phase-change materials (PCMs) offers a highly effective approach to improve ...
Sanchez-Vicente, Yolanda   +3 more
core   +2 more sources

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