Results 121 to 130 of about 15,777,493 (301)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

A novel top-down fabrication process for Ge2Sb2Te5 phase change material nanowires

, 2013
A novel e-beam free, top-down spacer etch process was used to fabricate sub-hundred nanometer Ge2Sb2Te5 phase change nanowires. Naowires with a cross-section dimension of 50 nm × 100 nm (width × height) were obtained and phase change functionality ...
Hector, Andrew L., Chen, Ruiqi, Ruomeng Huang, Ruiqi Chen, Kiang, Kian Shen, CH De Groot, de Groot, C.H., Hewak, Daniel W., Yudong Wang, Wang, Yudong, Kai Sun, Reid, Gillian, Behrad Gholipour, Andrew L. Hector, Sun, Kai, Daniel W. Hewak, Gillian Reid, Gholipour, Behrad, Huang, Ruomeng, Kian S. Kiang   +19 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Improving the energy efficient of manufactured lightweight housing: Integrating phase-change material with passive solar design [PDF]

, 2008
Improving the energy efficiency of the built environment is fundamental to slowing the current increase in atmospheric greenhouse gases and hence global warming. Thermal energy storage in buildings is a key component of energy conservation and the use of
Goodfield, David
core  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Versatile spaceborne photonics with chalcogenide phase-change materials

npj Microgravity
Recent growth in space systems has seen increasing capabilities packed into smaller and lighter Earth observation and deep space mission spacecraft. Phase-change materials (PCMs) are nonvolatile, reconfigurable, fast-switching, and have recently shown a ...
Hyun Jung Kim, Matthew Julian, Calum Williams, David Bombara, Juejun Hu, Tian Gu, Kiumars Aryana, Godfrey Sauti, William Humphreys   +8 more
doaj   +1 more source

Review of Thermal Energy Storage Materials for Application in Large-Scale Integrated Energy Systems—Methodology for Matching Heat Storage Solutions for Given Applications

Energies
This article is a broad literature review of materials used and defined as potential for heat storage processes. Both single-phase and phase-change materials were considered.
Michał Jurczyk, Tomasz Spietz, Agata Czardybon, Szymon Dobras, Karina Ignasiak, Łukasz Bartela, Wojciech Uchman, Jakub Ochmann   +7 more
doaj   +1 more source

Phase‐Change and Ovonic Materials (Second Edition) [PDF]

physica status solidi (RRL) – Rapid Research Letters, 2021
Noé, Pierre, Kooi, Bart J., Wuttig, Matthias   +2 more
openaire   +2 more sources

New hydrogen storage/phase change materials and their thermochemistry studies

, 2012
New hydrogen storage phase change materials and their thermochemistry ...
孙立贤
core  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source