Results 111 to 120 of about 21,023,140 (292)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Simple implementation examples of agent AI on free energy calculation and phase-field simulation

Science and Technology of Advanced Materials: Methods
With the development of an environment that equips large language models with tools, chat-type artificial intelligence (AI) is currently shifting to agent-type AI.
Toshiyuki Koyama, Yusuke Matsuoka, Akimitsu Ishii   +2 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

An Electrohydrodynamic Phase-Field Model for Contact Angle Hysteresis in Electrowetting Pixels: Decoupling Physical Pinning and Charge Trapping

Micromachines
Precise manipulation of two-phase flow in micro-confined electrowetting pixels is limited by contact angle hysteresis (CAH). To elucidate this non-equilibrium process, we establish a high-fidelity electrohydrodynamic (EHD) phase-field simulation ...
Qingsong Lu, Li Wang, Feng Li, Yanjun Yang, Qifu Liu, Xinying Wang, Feng Chi, Liming Liu, Zichuan Yi   +8 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Constitutive Modelling of Sintered Steel by Phase-field Method

Procedia Structural Integrity
The phase-field method is lately one of the most popular approaches for modelling of complex fracture phenomena. As known, the displacement field and phase-field variable cannot be determined simultaneously, except for easy problems, due to non-convexity of the energy functional.
Tomislav Polančec, Tomislav Lesičar, Jakov Rako   +2 more
openaire   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

A phase-field and Fourier neural operator-based method for predicting crack evolution in column-shell structures

Baozha yu Chongji
With the increasing application of engineering structures under extreme conditions, accurately predicting their fracture behavior has become a critical challenge in materials science and fracture mechanics.
Yadong QIE, Xiang LI, Songlin YAO, Hao ZHANG   +3 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source