Results 61 to 70 of about 768,945 (215)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Perancangan Sistem Modulator Binary Phase Shift Keying

Techne, 2016
Sistem yang dibangun adalah sebuah modul sistem modulator BPSK (Binary Phase Shift Keying). Perangkat yang dibahas adalah modulator BPSK dengan frekuensi 10kHz-48kHz dan untuk transmisi secara nirkabel ditambahkan pemancar FM yang akan mentranslasikan ...
Deddy Susilo, Budihardja Murtianta, Arivia Aurelia Devina P.   +2 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

EFFECT OF PHASE-SHIFT INTERFERENCE ON THE NOISE IMMUNITY OF CORRELATION DEMODULATOR OF SIGNALS WITH MULTIPLE PHASE SHIFT KEYING

Российский технологический журнал, 2019
The energy and spectral advantages of signals with phase shift keying predetermined their widespread use in modern digital navigation, communications and television systems. The use of such signals is the base of communication standards of DVB-S, DVB-S2 /
Gennady V. Kulikov, Van Dung Nguyen, Trung Tien Do   +2 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Variable phase equation in quantum scattering

Revista Brasileira de Ensino de Física
This paper presents the derivation and applications of the variable phase equation for single channel quantum scattering. The approach was first presented in 1933 by Morse and Allis and is based on a modification of the Schrödinger equation to a first ...
Vitor D. Viterbo, Nelson H.T. Lemes, João P. Braga   +2 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Detecting the Extremely Small Angle of an Axicon by Phase-Shifting Digital Holography

Applied Sciences, 2019
Axicon is an optical element that can be used to produce high-quality Bessel beams efficiently. In general, the smaller the base angle of the axicon is, the longer the diffraction-free distance of the generated Bessel beam will be. Therefore, axicon with
Yuchuan Zheng, Li Chen, Weiru Fan, Xiansheng Hu, Ziyang Chen, Jixiong Pu   +5 more
doaj   +1 more source