Results 221 to 230 of about 287,761 (311)

Sensitivity analysis in Bayesian clinical trials was underused and poorly reported: a systematic survey. [PDF]

BMC Med Res Methodol
Yao M, Huan J, Liang Q, Jie W, Wang M, Ma Y, Mei F, Liu Y, Xiong Y, Li L, Sun X.   +10 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Distributions of medial-lateral head sway (x) for all participants, measured relative the head position set point (x*) shown across A) manipulations of types of information in the test phase, and B) the trough width (w) parameter of the tactor activation function in the training phase.

Steven J. Harrison (22530308), Benjamin De Bari (6751766), Ryan Poutre (22530311), Jeffrey M. Kinsella-Shaw (22530314)   +3 more
openalex   +1 more source

Leveraging Pretrained Neural Network Models for the Classification of Tumor Cells Analyzed by Label-Free Phase Holotomographic Microscopy. [PDF]

Comput Struct Biotechnol J
Losa LVC, Douglas TA, Santos L, Monteiro R, Calejo I, Canadas RF, Nieder JB.   +6 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Wavelength-tunable high-Q circular dichroism based on the hybrid chiral phase-change metasurface. [PDF]

iScience
Zhou X, Zhang YJ, Zhang DQ, Fang B, Pan GM, Hong Z, Jin ZW, Shu FZ.   +7 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Detection of Irregular Loads Using SAW Delay-Line Devices. [PDF]

Sensors (Basel)
Yin Y, Zhao Z, You R, Liang Y, Wang W.
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Compact and programmable large-scale optical processor in free space. [PDF]

Light Sci Appl
Ammendola MG, Dehghan N, Scarfe L, D'Errico A, Di Colandrea F, Karimi E, Cardano F.   +6 more
europepmc   +1 more source