Results 131 to 140 of about 4,031,675 (267)

Emerging treatments for Sjögren's disease: promising drugs on the horizon. [PDF]

RMD Open
Marques-Gomes C, Bowman SJ, Nayar S, Fisher BA.   +3 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Reply to “Urine-based detection of HPV for cervical cancer screening: towards clinical implementation”

Journal of Clinical Microbiology
Sharmila Manjeshwar, Noah Kojima, Eric Tsang, David Pereira, Emmanuel Silva, Ha Duong, Felix Chao, Daniel R. Marshak, Ricky Y. T. Chiu, Jeffrey D. Klausner   +9 more
doaj   +1 more source

Radiologists' memory as a data protection risk: a worst-case stress test for chest radiograph re-identification. [PDF]

Insights Imaging
Fink MA, Römer C, Ebel M, Frodl E, Dos Santos DP, Kauczor HU, Bucher A.   +6 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Numerical Simulations of the Superfluid 3 He Order Parameter Using dyGiLa: A Homogeneous Rapid Quench to B Phase. [PDF]

J Low Temp Phys
Lopez-Eiguren A, Hindmarsh M, Rummukainen K, Zhang K.   +3 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Probing different time-scales of oscillatory fluctuations in visual awareness: from behavior to phase.

Frontiers in Human Neuroscience, 2010
Nienke eHoogenboom, Vincenzo eRomei, Vincenzo eRomei   +2 more
doaj   +1 more source

Altered light-dark phase-dependent behavioral responses and suprachiasmatic nucleus pathology in an α-synuclein rat model of Parkinson's disease. [PDF]

NPJ Parkinsons Dis
Weber H, Statz M, Casadei N, Riess O, Richter F, Hermann W, Storch A, Fauser M.   +7 more
europepmc   +1 more source