Results 31 to 40 of about 23,492 (260)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

High-Resolution and Wide-Swath SAR Imaging with Space–Time Coding Array

Remote Sensing, 2023
To achieve high-resolution and wide-swath (HRWS) synthetic aperture radar (SAR) images, this paper focuses on resolving the problem of separating range-ambiguous echoes with the space–time coding (STC) array.
Kun Yu, Shengqi Zhu, Lan Lan, Biao Yang
doaj   +1 more source

Prediction of phase ambiguity resolution based on signal intensity and geometry [PDF]

GPS Solutions, 2014
The goal of this contribution was to develop a reliable quality indicator reflecting the potential success of differential carrier phase ambiguity resolution for kinematic Global Positioning System (GPS). The indicator must be operable without any communication link between the rover and the reference station.
Daniel Willi, Jan Skaloud
openaire   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

High‐Resolution MRI Revealed Different Etiology‐Specific Associations With Cerebral Infarction in Adult Moyamoya Vasculopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐resolution MRI enables detailed assessment of intracranial vessel wall pathology in moyamoya vasculopathy. We aimed to classify adult moyamoya vasculopathy etiologies using high‐resolution MRI and to examine subtype‐specific associations between high‐resolution MRI features and ischemic infarction.
Guangsong Han, Jiachun Pan, Yuehui Hong, Xiaoyuan Fan, Ming Yao, Lixin Zhou, Yicheng Zhu, Feng Feng, Jun Ni   +8 more
wiley   +1 more source

An Integer Ambiguity Resolution Method Based on the Hybrid Adaptive Differential Evolution Grey Wolf Optimizer Algorithm

Algorithms
In Global Navigation Satellite Systems (GNSS), high-precision position coordinates are typically determined by establishing a double-difference carrier phase observation model and resolving the integer ambiguities within it. Therefore, the ability to fix
Jiangchao Tian, Xiyan Sun, Yuanfa Ji, Wuzheng Guo, Xizi Jia   +4 more
doaj   +1 more source

Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro, Shiwen Koay, Gordon T. Ingle, Patricia McNamara, Laura Watson, Fion Bremner, Valeria Iodice   +6 more
wiley   +1 more source

Ambiguity Resolution for Passive 2-D Source Localization with a Uniform Circular Array

Sensors, 2018
This paper proposes two novel phase-based algorithms for the passive localization of a single source with a uniform circular array (UCA) under the case of measuring phase ambiguity based on two phase difference observation models, which are defined as ...
Jinlong Xin, Guisheng Liao, Zhiwei Yang, Haoming Shen   +3 more
doaj   +1 more source

Ambiguity Resolution for Long Baseline in a Network with BDS-3 Quad-Frequency Ionosphere-Weighted Model

Remote Sensing, 2022
For long baseline in a network, the traditional combined ionosphere-free (IF) + wide-lane (WL) strategy is commonly used, but the residual tropospheric delays and larger noise hamper the basic ambiguity resolution (AR).
Ruicheng Zhang, Chengfa Gao, Zhibin Wang, Qing Zhao, Rui Shang, Zihan Peng, Qi Liu   +6 more
doaj   +1 more source