Results 101 to 110 of about 28,526,403 (303)

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Second order phase field asymptotics for multi-component systems [PDF]

open access: yes, 2006
An asymptotic analysis of a phase field model for solidification in multicomponent alloy systems is presented. In the limit of vanishing interface thickness the related sharp interface model is approximated to second order by taking a non-constant ...
Stinner, Björn, Garcke, Harald
core   +1 more source

Excessive Fe Contamination in Secondary Al Alloys: Microstructure, Porosity, and Corrosion Behaviour

open access: yesMetals
The characterisation of aluminium casting alloys with iron concentrations exceeding current standards is essential, as upcycling has recently become a significant concern in achieving a more circular economy.
Helder Nunes   +4 more
doaj   +1 more source

Left Ventricular Dyssynchrony Parameters Measured by Phase Analysis of Post-stress and Resting Gated SPECT Myocardial Perfusion Imaging

open access: yesWorld Journal of Nuclear Medicine, 2013
Phase analysis has been validated to measure left ventricular (LV) dyssynchrony from resting gated SPECT myocardial perfusion imaging (MPI). In 1-day rest/stress protocols, often only post-stress gated data are acquired.
Yanli Zhou   +6 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Phase Analysis of Pt, Pd and Au in Black Rock-type Platinum Group Element Minerals by ICP-MS

open access: yesYankuang ceshi, 2017
Black rock as an important carrier of platinum group elements was discovered in recent years. Due to the multiple origins and complex mineralization, the distribution and occurrence of platinum group elements in black rock are not clear, which is also ...
LIAN Wen-li   +7 more
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Numerical analysis of a relaxed variational model of hysteresis in two-phase solids [PDF]

open access: yes, 2001
This paper presents the numerical analysis for a variational formulation of rate-independent phase transformations in elastic solids due to Mielke et al.
Carstensen, Carsten   +3 more
core   +1 more source

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