Results 201 to 210 of about 3,995,176 (315)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Exploring Burnout at the Morgue During the COVID-19 Pandemic: A Three-Phase Analysis of Forensic and Pathology Personnel. [PDF]

Healthcare (Basel)
Oprinca-Muja LA, Cristian AN, Topîrcean E, Cristian A, Popa MF, Cardoș R, Oprinca GC, Atasie D, Mihalache C, Bucuță MD, Morar S.   +10 more
europepmc   +1 more source

Morlet Wavelet Filtering and Phase Analysis to Reduce the Limit of Detection for Thin Film Optical Biosensors. [PDF]

ACS Sens, 2021
Ward SJ, Layouni R, Arshavsky-Graham S, Segal E, Weiss SM.   +4 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Electron Holography for Advanced Characterization of Permanent Magnets: Demagnetization Field Mapping and Enhanced Precision in Phase Analysis. [PDF]

Nanomaterials (Basel)
Lee S.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Exploring Chinese Consumers' Attitudes Towards Pet Nutritional Products and Their Continuous Purchase Intentions: A Dual-Phase Analysis Using SEM and ANN. [PDF]

Behav Sci (Basel)
Jin J, Yang B.
europepmc   +1 more source

Compression and broadening of phase-conjugate pulses in photorefractive self-pumped phase conjugator

, 2000
Pulse propagation and shaping are investigated in photorefractive self-pumped phase conjugators in both transmission- and reflection-grating regimes. The dispersion properties of self-pumped phase conjugators are analyzed by taking into account both the ...
Kaczmarek, Malgosia, Yang, Changxi, Xiao, Min   +2 more
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Geometric phase analysis of magnetic skyrmion lattices in Lorentz transmission electron microscopy images. [PDF]

Sci Rep
Denneulin T, Kovács A, Boltje R, Kiselev NS, Dunin-Borkowski RE.   +4 more
europepmc   +1 more source