Results 221 to 230 of about 26,026,661 (311)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

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2H–2M Phase Control of WSe2 Nanosheets by Se Enrichment Toward Enhanced Electrocatalytic Hydrogen Evolution Reaction

Advances in Materials, 2023
The phase control of transition metal dichalcogenides (TMDs) is an intriguing approach for tuning the electronic structure toward extensive applications.
Ik Seon Kwon, I. Kwak, Ju Yeon Kim, Seung Jae Lee, Qadeer Akbar Sial, Junaid Ihsan, Kug‐Seung Lee, Seung Jo Yoo, Jeunghee Park, H. Kang   +9 more
semanticscholar   +1 more source

Novel Passive Vector-Sum Reconfigurable Filtering Phase Shifter With Continuous Phase-Control and Tunable Center Frequency

IEEE transactions on microwave theory and techniques, 2022
In this article, a novel reconfigurable filtering vector-sum phase shifter (RFPS) with a continuous phase shift range of $\ge 300^{\circ }$ and tunable operating frequency range from 1.05 to 1.3 GHz is proposed.
Xu Zhu, Tao Yang, P. Chi, Ruimin Xu
semanticscholar   +1 more source

A Pattern Reconfigurable Circularly Polarized Quadrifilar Helix Antenna Through Phase Control

IEEE Transactions on Antennas and Propagation, 2022
We have proved in theory and simulation that the circularly polarized (CP) radiation from a resonant quadrifilar helix antenna (QHA) is independent of the phase between two composed bifilar helices while the CP radiation pattern can be reconfigured by ...
Wenjian Sun, G. Su, L. Sun, Xiao-dong Chen   +3 more
semanticscholar   +1 more source

Phase Control of Cs-Pb-Br Derivatives to Suppress 0D Cs4 PbBr6 for High-Efficiency and Stable All-Inorganic CsPbBr3 Perovskite Solar Cells.

Small, 2021
The precise phase control of Cs-Pb-Br derivatives from 3D CsPbBr3 to 0D Cs4 PbBr6 highly determines the photovoltaic performance of all-inorganic CsPbBr3 perovskite solar cells (PSCs).
Jingwei Zhu, B. He, Xinpeng Yao, Haiyan Chen, Yanyan Duan, Jialong Duan, Q. Tang   +6 more
semanticscholar   +1 more source

Dual-band independent phase control based on high efficiency metasurface [Invited]

Chinese Optics Letters (COL), 2021
A general method to realize arbitrary dual-band independent phase control is proposed and demonstrated in this paper. A double-layered C-shape reflective meta-atom is designed to realize independent phase control with high efficiency.
Jinxing Li, Yueyi Yuan, Qun Wu, S. Burokur, Kuang Zhang   +4 more
semanticscholar   +1 more source

A Dual-Band, Polarization-Rotating Reflectarray With Independent Phase Control at Each Band

IEEE Transactions on Antennas and Propagation, 2021
We present the design and proof-of-concept demonstration of a dual-band reflectarray antenna capable of generating two beams at $X$ - and $Ku$ -bands, whose directions of maximum radiation can be set independently of each other.
Zongtang Zhang, H. Luyen, J. Booske, N. Behdad   +3 more
semanticscholar   +1 more source